Cooperative melting in caged dimers with only two DNA duplexes

Ibrahim Eryazici, Tatiana R. Prytkova, George C. Schatz, Sonbinh T. Nguyen

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH 2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.

Original languageEnglish
Pages (from-to)17068-17070
Number of pages3
JournalJournal of the American Chemical Society
Volume132
Issue number48
DOIs
Publication statusPublished - Dec 8 2010

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ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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