Cooperative melting in caged dimers with only two DNA duplexes

Ibrahim Eryazici; Tatiana R. Prytkova; George C Schatz; Sonbinh T. Nguyen

doi:10.1021/ja107232x

Cooperative melting in caged dimers with only two DNA duplexes

Ibrahim Eryazici, Tatiana R. Prytkova, George C Schatz, Sonbinh T. Nguyen

Northwestern University

Research output: Contribution to journal › Article

32 Citations (Scopus)

Abstract

Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH ₂) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.

Original language	English
Pages (from-to)	17068-17070
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	132
Issue number	48
DOIs	https://doi.org/10.1021/ja107232x
Publication status	Published - Dec 8 2010

Fingerprint

Dimers

Freezing

Melting

DNA

Thermodynamics

Analytical models

Molecules

Computer simulation

ASJC Scopus subject areas

Chemistry(all)
Catalysis
Biochemistry
Colloid and Surface Chemistry

Cite this

Eryazici, I., Prytkova, T. R., Schatz, G. C., & Nguyen, S. T. (2010). Cooperative melting in caged dimers with only two DNA duplexes. Journal of the American Chemical Society, 132(48), 17068-17070. https://doi.org/10.1021/ja107232x

Cooperative melting in caged dimers with only two DNA duplexes. / Eryazici, Ibrahim; Prytkova, Tatiana R.; Schatz, George C; Nguyen, Sonbinh T.

In: Journal of the American Chemical Society, Vol. 132, No. 48, 08.12.2010, p. 17068-17070.

Research output: Contribution to journal › Article

Eryazici, I, Prytkova, TR, Schatz, GC & Nguyen, ST 2010, 'Cooperative melting in caged dimers with only two DNA duplexes', Journal of the American Chemical Society, vol. 132, no. 48, pp. 17068-17070. https://doi.org/10.1021/ja107232x

Eryazici I, Prytkova TR, Schatz GC, Nguyen ST. Cooperative melting in caged dimers with only two DNA duplexes. Journal of the American Chemical Society. 2010 Dec 8;132(48):17068-17070. https://doi.org/10.1021/ja107232x

Eryazici, Ibrahim ; Prytkova, Tatiana R. ; Schatz, George C ; Nguyen, Sonbinh T. / Cooperative melting in caged dimers with only two DNA duplexes. In: Journal of the American Chemical Society. 2010 ; Vol. 132, No. 48. pp. 17068-17070.

@article{fabbc29ff3384cd09333fe186ca57a98,

title = "Cooperative melting in caged dimers with only two DNA duplexes",

abstract = "Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH 2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.",

author = "Ibrahim Eryazici and Prytkova, {Tatiana R.} and Schatz, {George C} and Nguyen, {Sonbinh T.}",

year = "2010",

month = "12",

day = "8",

doi = "10.1021/ja107232x",

language = "English",

volume = "132",

pages = "17068--17070",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "48",

}

TY - JOUR

T1 - Cooperative melting in caged dimers with only two DNA duplexes

AU - Eryazici, Ibrahim

AU - Prytkova, Tatiana R.

AU - Schatz, George C

AU - Nguyen, Sonbinh T.

PY - 2010/12/8

Y1 - 2010/12/8

N2 - Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH 2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.

AB - Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH 2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.

UR - http://www.scopus.com/inward/record.url?scp=78650119982&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650119982&partnerID=8YFLogxK

U2 - 10.1021/ja107232x

DO - 10.1021/ja107232x

M3 - Article

C2 - 21073153

AN - SCOPUS:78650119982

VL - 132

SP - 17068

EP - 17070

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 48

ER -

Access to Document

10.1021/ja107232x