Cooperative melting in caged dimers with only two DNA duplexes

Ibrahim Eryazici; Tatiana R. Prytkova; George C. Schatz; Sonbinh T. Nguyen

doi:10.1021/ja107232x

Cooperative melting in caged dimers with only two DNA duplexes

Ibrahim Eryazici, Tatiana R. Prytkova, George C. Schatz, Sonbinh T. Nguyen

Northwestern University

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH ₂) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.

Original language	English
Pages (from-to)	17068-17070
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	132
Issue number	48
DOIs	https://doi.org/10.1021/ja107232x
Publication status	Published - Dec 8 2010

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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title = "Cooperative melting in caged dimers with only two DNA duplexes",

abstract = "Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH 2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.",

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AU - Schatz, George C.

AU - Nguyen, Sonbinh T.

PY - 2010/12/8

Y1 - 2010/12/8

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AB - Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH 2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.

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Cooperative melting in caged dimers with only two DNA duplexes

Abstract

ASJC Scopus subject areas

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