Cooperative melting in caged dimers with only two DNA duplexes

Ibrahim Eryazici; Tatiana R. Prytkova; George C. Schatz; Sonbinh T. Nguyen

doi:10.1021/ja107232x

Cooperative melting in caged dimers with only two DNA duplexes

Ibrahim Eryazici, Tatiana R. Prytkova, George C. Schatz, Sonbinh T. Nguyen

Northwestern University

Research output: Contribution to journal › Article

32 Citations (Scopus)

Abstract

Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH ₂) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.

Original language	English
Pages (from-to)	17068-17070
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	132
Issue number	48
DOIs	https://doi.org/10.1021/ja107232x
Publication status	Published - Dec 8 2010

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

Access to Document

10.1021/ja107232x

Fingerprint Dive into the research topics of 'Cooperative melting in caged dimers with only two DNA duplexes'. Together they form a unique fingerprint.

Cite this

Eryazici, I., Prytkova, T. R., Schatz, G. C., & Nguyen, S. T. (2010). Cooperative melting in caged dimers with only two DNA duplexes. Journal of the American Chemical Society, 132(48), 17068-17070. https://doi.org/10.1021/ja107232x

@article{fabbc29ff3384cd09333fe186ca57a98,

title = "Cooperative melting in caged dimers with only two DNA duplexes",

abstract = "Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH 2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.",

author = "Ibrahim Eryazici and Prytkova, {Tatiana R.} and Schatz, {George C.} and Nguyen, {Sonbinh T.}",

year = "2010",

month = dec,

day = "8",

doi = "10.1021/ja107232x",

language = "English",

volume = "132",

pages = "17068--17070",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "48",

}

TY - JOUR

T1 - Cooperative melting in caged dimers with only two DNA duplexes

AU - Eryazici, Ibrahim

AU - Prytkova, Tatiana R.

AU - Schatz, George C.

AU - Nguyen, Sonbinh T.

PY - 2010/12/8

Y1 - 2010/12/8

N2 - Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH 2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.

AB - Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH 2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.

UR - http://www.scopus.com/inward/record.url?scp=78650119982&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650119982&partnerID=8YFLogxK

U2 - 10.1021/ja107232x

DO - 10.1021/ja107232x

M3 - Article

C2 - 21073153

AN - SCOPUS:78650119982

VL - 132

SP - 17068

EP - 17070

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 48

ER -