Cooperative melting in caged dimers with only two DNA duplexes

Ibrahim Eryazici; Tatiana R. Prytkova; George C Schatz; Sonbinh T. Nguyen

doi:10.1021/ja107232x

Cooperative melting in caged dimers with only two DNA duplexes

Ibrahim Eryazici, Tatiana R. Prytkova, George C Schatz, Sonbinh T. Nguyen

Northwestern University

Research output: Contribution to journal › Article

32 Citations (Scopus)

Abstract

Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH ₂) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.

Original language	English
Pages (from-to)	17068-17070
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	132
Issue number	48
DOIs	https://doi.org/10.1021/ja107232x
Publication status	Published - Dec 8 2010

Fingerprint

Dimers

Freezing

Melting

DNA

Thermodynamics

Analytical models

Molecules

Computer simulation

ASJC Scopus subject areas

Chemistry(all)
Catalysis
Biochemistry
Colloid and Surface Chemistry

Cite this

Eryazici, I., Prytkova, T. R., Schatz, G. C., & Nguyen, S. T. (2010). Cooperative melting in caged dimers with only two DNA duplexes. Journal of the American Chemical Society, 132(48), 17068-17070. https://doi.org/10.1021/ja107232x

Cooperative melting in caged dimers with only two DNA duplexes. / Eryazici, Ibrahim; Prytkova, Tatiana R.; Schatz, George C; Nguyen, Sonbinh T.

In: Journal of the American Chemical Society, Vol. 132, No. 48, 08.12.2010, p. 17068-17070.

Research output: Contribution to journal › Article

Eryazici, I, Prytkova, TR, Schatz, GC & Nguyen, ST 2010, 'Cooperative melting in caged dimers with only two DNA duplexes', Journal of the American Chemical Society, vol. 132, no. 48, pp. 17068-17070. https://doi.org/10.1021/ja107232x

Eryazici I, Prytkova TR, Schatz GC, Nguyen ST. Cooperative melting in caged dimers with only two DNA duplexes. Journal of the American Chemical Society. 2010 Dec 8;132(48):17068-17070. https://doi.org/10.1021/ja107232x

Eryazici, Ibrahim ; Prytkova, Tatiana R. ; Schatz, George C ; Nguyen, Sonbinh T. / Cooperative melting in caged dimers with only two DNA duplexes. In: Journal of the American Chemical Society. 2010 ; Vol. 132, No. 48. pp. 17068-17070.

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Access to Document

10.1021/ja107232x