Abstract
Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH 2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.
Original language | English |
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Pages (from-to) | 17068-17070 |
Number of pages | 3 |
Journal | Journal of the American Chemical Society |
Volume | 132 |
Issue number | 48 |
DOIs | |
Publication status | Published - Dec 8 2010 |
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry