Cooperative melting in caged dimers with only two DNA duplexes

Ibrahim Eryazici, Tatiana R. Prytkova, George C Schatz, Sonbinh T. Nguyen

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH 2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.

Original languageEnglish
Pages (from-to)17068-17070
Number of pages3
JournalJournal of the American Chemical Society
Volume132
Issue number48
DOIs
Publication statusPublished - Dec 8 2010

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Dimers
Freezing
Melting
DNA
Thermodynamics
Analytical models
Molecules
Computer simulation

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Cooperative melting in caged dimers with only two DNA duplexes. / Eryazici, Ibrahim; Prytkova, Tatiana R.; Schatz, George C; Nguyen, Sonbinh T.

In: Journal of the American Chemical Society, Vol. 132, No. 48, 08.12.2010, p. 17068-17070.

Research output: Contribution to journalArticle

Eryazici, Ibrahim ; Prytkova, Tatiana R. ; Schatz, George C ; Nguyen, Sonbinh T. / Cooperative melting in caged dimers with only two DNA duplexes. In: Journal of the American Chemical Society. 2010 ; Vol. 132, No. 48. pp. 17068-17070.
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