Cytotoxicity of mesoporous silica nanomaterials

Anthony J. Di Pasqua, Krishna K. Sharma, Yan Li Shi, Bonnie B. Toms, Wayne Ouellette, James C. Dabrowiak, Teddy Asefa

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

We here measure the toxicity of MCM-41, a mesoporous silica nanomaterial, two of its functionalized analogs, AP-T, which has grafted aminopropyl groups and MP-T, which has grafted mercaptopropyl groups, and spherical silica nanoparticles (SiO2), toward human neuroblastoma (SK-N-SH) cells. Since the particles studied are not soluble in aqueous media, the metric used to report the cytotoxicity of these materials is a new quantity, Q50, which is the number of particles required to inhibit normal cell growth by 50%. Determining the number of particles per gram of material applied to the cells required both the calculated and experimentally determined surface areas of these nanomaterials. This study shows that Q50 increases in the order, MCM-41 <MP-T <AP-T ≈ SiO2, showing that on a per particle basis, MCM-41 is the most cytotoxic material studied. For the three mesoporous silica materials in this study, cytotoxicity appears related to the adsorptive surface area of the particle, although the nature of the functional group cannot be ruled out. Silica nanospheres have the lowest surface area of the particles studied but since they exhibit a Q50 value similar to that of AP-T, shape may also be important in the cytotoxicity of these materials.

Original languageEnglish
Pages (from-to)1416-1423
Number of pages8
JournalJournal of Inorganic Biochemistry
Volume102
Issue number7
DOIs
Publication statusPublished - Jul 2008

Fingerprint

Nanostructures
Cytotoxicity
Nanostructured materials
Silicon Dioxide
Nanospheres
Neuroblastoma
Nanoparticles
Cell growth
Functional groups
Toxicity
Growth
MCM-41

Keywords

  • Cells
  • Cytotoxicity
  • Mesoporous silica
  • Nanomaterials

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Di Pasqua, A. J., Sharma, K. K., Shi, Y. L., Toms, B. B., Ouellette, W., Dabrowiak, J. C., & Asefa, T. (2008). Cytotoxicity of mesoporous silica nanomaterials. Journal of Inorganic Biochemistry, 102(7), 1416-1423. https://doi.org/10.1016/j.jinorgbio.2007.12.028

Cytotoxicity of mesoporous silica nanomaterials. / Di Pasqua, Anthony J.; Sharma, Krishna K.; Shi, Yan Li; Toms, Bonnie B.; Ouellette, Wayne; Dabrowiak, James C.; Asefa, Teddy.

In: Journal of Inorganic Biochemistry, Vol. 102, No. 7, 07.2008, p. 1416-1423.

Research output: Contribution to journalArticle

Di Pasqua, AJ, Sharma, KK, Shi, YL, Toms, BB, Ouellette, W, Dabrowiak, JC & Asefa, T 2008, 'Cytotoxicity of mesoporous silica nanomaterials', Journal of Inorganic Biochemistry, vol. 102, no. 7, pp. 1416-1423. https://doi.org/10.1016/j.jinorgbio.2007.12.028
Di Pasqua AJ, Sharma KK, Shi YL, Toms BB, Ouellette W, Dabrowiak JC et al. Cytotoxicity of mesoporous silica nanomaterials. Journal of Inorganic Biochemistry. 2008 Jul;102(7):1416-1423. https://doi.org/10.1016/j.jinorgbio.2007.12.028
Di Pasqua, Anthony J. ; Sharma, Krishna K. ; Shi, Yan Li ; Toms, Bonnie B. ; Ouellette, Wayne ; Dabrowiak, James C. ; Asefa, Teddy. / Cytotoxicity of mesoporous silica nanomaterials. In: Journal of Inorganic Biochemistry. 2008 ; Vol. 102, No. 7. pp. 1416-1423.
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