De novo design of functional proteins: Toward artificial hydrogenases

Marina Faiella, Anindya Roy, Dayn Sommer, Giovanna Ghirlanda

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Over the last 25 years, de novo design has proven to be a valid approach to generate novel, well-folded proteins, and most recently, functional proteins. In response to societal needs, this approach is been used increasingly to design functional proteins developed with an eye toward sustainable fuel production. This review surveys recent examples of bioinspired de novo designed peptide based catalysts, focusing in particular on artificial hydrogenases.

Original languageEnglish
Pages (from-to)558-571
Number of pages14
JournalBiopolymers
Volume100
Issue number6
DOIs
Publication statusPublished - Nov 2013

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Keywords

  • Catalysis
  • De novo design
  • Hydrogenase
  • Iron-sulfur clusters
  • Peptide

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Biomaterials
  • Organic Chemistry

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