De novo design of functional proteins

Toward artificial hydrogenases

Marina Faiella, Anindya Roy, Dayn Sommer, Giovanna Ghirlanda

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Over the last 25 years, de novo design has proven to be a valid approach to generate novel, well-folded proteins, and most recently, functional proteins. In response to societal needs, this approach is been used increasingly to design functional proteins developed with an eye toward sustainable fuel production. This review surveys recent examples of bioinspired de novo designed peptide based catalysts, focusing in particular on artificial hydrogenases.

Original languageEnglish
Pages (from-to)558-571
Number of pages14
JournalBiopolymers
Volume100
Issue number6
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Hydrogenase
Proteins
Peptides
Catalysts

Keywords

  • Catalysis
  • De novo design
  • Hydrogenase
  • Iron-sulfur clusters
  • Peptide

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biomaterials
  • Organic Chemistry

Cite this

De novo design of functional proteins : Toward artificial hydrogenases. / Faiella, Marina; Roy, Anindya; Sommer, Dayn; Ghirlanda, Giovanna.

In: Biopolymers, Vol. 100, No. 6, 11.2013, p. 558-571.

Research output: Contribution to journalArticle

Faiella, Marina ; Roy, Anindya ; Sommer, Dayn ; Ghirlanda, Giovanna. / De novo design of functional proteins : Toward artificial hydrogenases. In: Biopolymers. 2013 ; Vol. 100, No. 6. pp. 558-571.
@article{b18da52c453043d393271e6cefc547df,
title = "De novo design of functional proteins: Toward artificial hydrogenases",
abstract = "Over the last 25 years, de novo design has proven to be a valid approach to generate novel, well-folded proteins, and most recently, functional proteins. In response to societal needs, this approach is been used increasingly to design functional proteins developed with an eye toward sustainable fuel production. This review surveys recent examples of bioinspired de novo designed peptide based catalysts, focusing in particular on artificial hydrogenases.",
keywords = "Catalysis, De novo design, Hydrogenase, Iron-sulfur clusters, Peptide",
author = "Marina Faiella and Anindya Roy and Dayn Sommer and Giovanna Ghirlanda",
year = "2013",
month = "11",
doi = "10.1002/bip.22420",
language = "English",
volume = "100",
pages = "558--571",
journal = "Biopolymers",
issn = "0006-3525",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - De novo design of functional proteins

T2 - Toward artificial hydrogenases

AU - Faiella, Marina

AU - Roy, Anindya

AU - Sommer, Dayn

AU - Ghirlanda, Giovanna

PY - 2013/11

Y1 - 2013/11

N2 - Over the last 25 years, de novo design has proven to be a valid approach to generate novel, well-folded proteins, and most recently, functional proteins. In response to societal needs, this approach is been used increasingly to design functional proteins developed with an eye toward sustainable fuel production. This review surveys recent examples of bioinspired de novo designed peptide based catalysts, focusing in particular on artificial hydrogenases.

AB - Over the last 25 years, de novo design has proven to be a valid approach to generate novel, well-folded proteins, and most recently, functional proteins. In response to societal needs, this approach is been used increasingly to design functional proteins developed with an eye toward sustainable fuel production. This review surveys recent examples of bioinspired de novo designed peptide based catalysts, focusing in particular on artificial hydrogenases.

KW - Catalysis

KW - De novo design

KW - Hydrogenase

KW - Iron-sulfur clusters

KW - Peptide

UR - http://www.scopus.com/inward/record.url?scp=84891721646&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891721646&partnerID=8YFLogxK

U2 - 10.1002/bip.22420

DO - 10.1002/bip.22420

M3 - Article

VL - 100

SP - 558

EP - 571

JO - Biopolymers

JF - Biopolymers

SN - 0006-3525

IS - 6

ER -