Abstract
Two types of dendrimers with AB2 branching, one with acyloxysilanes at the branching position (V type) and the other at the non-branching position (Y type), were synthesized using hydrosilylation with chlorosilanes followed by heterofunctional condensation with olefin-functional carboxylic acids, and examined as readily degradable template materials. The V type dendrimer was much more susceptible to ligand redistribution with chlorosilanes during preparation, whereas the Y type was less. The acyloxysilane linkages in these dendrimers could be cleaved readily by alcoholysis or hydrolysis on demand, making for suitable templates.
| Original language | English |
|---|---|
| Pages (from-to) | 7502-7509 |
| Number of pages | 8 |
| Journal | Tetrahedron |
| Volume | 67 |
| Issue number | 39 |
| DOIs | |
| Publication status | Published - Sep 30 2011 |
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Keywords
- Acyloxysilane
- Degradable dendrimer
- Ligand redistribution
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
Cite this
Design and synthesis of readily degradable acyloxysilane dendrimers. / Downing, Christopher M.; Missaghi, Michael N.; Kung, Mayfair C.; Kung, Harold H.
In: Tetrahedron, Vol. 67, No. 39, 30.09.2011, p. 7502-7509.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Design and synthesis of readily degradable acyloxysilane dendrimers
AU - Downing, Christopher M.
AU - Missaghi, Michael N.
AU - Kung, Mayfair C.
AU - Kung, Harold H
PY - 2011/9/30
Y1 - 2011/9/30
N2 - Two types of dendrimers with AB2 branching, one with acyloxysilanes at the branching position (V type) and the other at the non-branching position (Y type), were synthesized using hydrosilylation with chlorosilanes followed by heterofunctional condensation with olefin-functional carboxylic acids, and examined as readily degradable template materials. The V type dendrimer was much more susceptible to ligand redistribution with chlorosilanes during preparation, whereas the Y type was less. The acyloxysilane linkages in these dendrimers could be cleaved readily by alcoholysis or hydrolysis on demand, making for suitable templates.
AB - Two types of dendrimers with AB2 branching, one with acyloxysilanes at the branching position (V type) and the other at the non-branching position (Y type), were synthesized using hydrosilylation with chlorosilanes followed by heterofunctional condensation with olefin-functional carboxylic acids, and examined as readily degradable template materials. The V type dendrimer was much more susceptible to ligand redistribution with chlorosilanes during preparation, whereas the Y type was less. The acyloxysilane linkages in these dendrimers could be cleaved readily by alcoholysis or hydrolysis on demand, making for suitable templates.
KW - Acyloxysilane
KW - Degradable dendrimer
KW - Ligand redistribution
UR - http://www.scopus.com/inward/record.url?scp=81155159817&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=81155159817&partnerID=8YFLogxK
U2 - 10.1016/j.tet.2011.07.068
DO - 10.1016/j.tet.2011.07.068
M3 - Article
VL - 67
SP - 7502
EP - 7509
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 39
ER -