Design and synthesis of readily degradable acyloxysilane dendrimers

Christopher M. Downing, Michael N. Missaghi, Mayfair C. Kung, Harold H. Kung

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Two types of dendrimers with AB2 branching, one with acyloxysilanes at the branching position (V type) and the other at the non-branching position (Y type), were synthesized using hydrosilylation with chlorosilanes followed by heterofunctional condensation with olefin-functional carboxylic acids, and examined as readily degradable template materials. The V type dendrimer was much more susceptible to ligand redistribution with chlorosilanes during preparation, whereas the Y type was less. The acyloxysilane linkages in these dendrimers could be cleaved readily by alcoholysis or hydrolysis on demand, making for suitable templates.

Original languageEnglish
Pages (from-to)7502-7509
Number of pages8
JournalTetrahedron
Volume67
Issue number39
DOIs
Publication statusPublished - Sep 30 2011

    Fingerprint

Keywords

  • Acyloxysilane
  • Degradable dendrimer
  • Ligand redistribution

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this