Design and synthesis of readily degradable acyloxysilane dendrimers

Christopher M. Downing, Michael N. Missaghi, Mayfair C. Kung, Harold H Kung

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Two types of dendrimers with AB2 branching, one with acyloxysilanes at the branching position (V type) and the other at the non-branching position (Y type), were synthesized using hydrosilylation with chlorosilanes followed by heterofunctional condensation with olefin-functional carboxylic acids, and examined as readily degradable template materials. The V type dendrimer was much more susceptible to ligand redistribution with chlorosilanes during preparation, whereas the Y type was less. The acyloxysilane linkages in these dendrimers could be cleaved readily by alcoholysis or hydrolysis on demand, making for suitable templates.

Original languageEnglish
Pages (from-to)7502-7509
Number of pages8
JournalTetrahedron
Volume67
Issue number39
DOIs
Publication statusPublished - Sep 30 2011

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Dendrimers
Hydrosilylation
Alkenes
Carboxylic Acids
Condensation
Hydrolysis
Ligands

Keywords

  • Acyloxysilane
  • Degradable dendrimer
  • Ligand redistribution

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Design and synthesis of readily degradable acyloxysilane dendrimers. / Downing, Christopher M.; Missaghi, Michael N.; Kung, Mayfair C.; Kung, Harold H.

In: Tetrahedron, Vol. 67, No. 39, 30.09.2011, p. 7502-7509.

Research output: Contribution to journalArticle

Downing, Christopher M. ; Missaghi, Michael N. ; Kung, Mayfair C. ; Kung, Harold H. / Design and synthesis of readily degradable acyloxysilane dendrimers. In: Tetrahedron. 2011 ; Vol. 67, No. 39. pp. 7502-7509.
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