Design of biomolecules for nanoengineered biomaterials for regenerative medicine

Alvaro Mata, Liam Palmer, Esther Tejeda-Montes, Samuel I. Stupp

Research output: Chapter in Book/Report/Conference proceedingChapter

22 Citations (Scopus)


An important goal in the development of highly functional organic materials is to design self-assembling molecules that can reproducibly display chemical signals across length scales. Within the biomedical field, biomolecules are highly attractive candidates to serve as bioactive building blocks for the next generation of biomaterials. The peptide amphiphiles (PAs) developed by the Stupp Laboratory at Northwestern University generated a highly versatile self-assembly code to create well-defined bioactive nanofibers that have been proven to be very effective at signaling cells in vitro and in vivo. Here, we describe the basic steps necessary for synthesis and assembly of PA molecules into functional nanostructures.

Original languageEnglish
Title of host publicationNanotechnology in Regenerative Medicine
Subtitle of host publicationMethods and Protocols
EditorsMelba Navarro, Josep Planell
Number of pages11
Publication statusPublished - Jan 1 2012

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Biomaterials
  • Biomolecules
  • Peptide amphiphiles
  • Peptide synthesis
  • Regenerative medicine

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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