Designer DNA Nanoarchitectures

Chenxiang Lin, Yan Liu, Hao Yan

Research output: Contribution to journalArticle

217 Citations (Scopus)

Abstract

Naturally existing biological systems, from the simplest unicellular diatom to the most sophisticated organ such as the human brain, are functional self-assembled architectures. Scientists have long been dreaming about building artificial nanostructures that can mimic such elegance in nature. Structural DNA nanotechnology, which uses DNA as a blueprint and building material to organize matter with nanometer precision, represents an appealing solution to this challenge. On the basis of the knowledge of helical DNA structure and Watson-Crick base pairing rules, scientists have constructed a number of DNA nanoarchitectures with a large variety of geometries, topologies, and periodicities with considerably high yields. Modified by functional groups, those DNA nanostructures can serve as scaffolds to control the positioning of other molecular species, which opens opportunities to study intermolecular synergies, such as protein-protein interactions, as well as to build artificial multicomponent nanomachines. In this review, we summarize the principle of DNA self-assembly, describe the exciting progress of structural DNA nanotechnology in recent years, and discuss the current frontier.

Original languageEnglish
Pages (from-to)1663-1674
Number of pages12
JournalBiochemistry
Volume48
Issue number8
DOIs
Publication statusPublished - Mar 3 2009

Fingerprint

DNA
Nanotechnology
Nanostructures
Diatoms
Blueprints
Periodicity
Biological systems
Scaffolds
Base Pairing
Self assembly
Functional groups
Brain
Proteins
Topology
Geometry

ASJC Scopus subject areas

  • Biochemistry

Cite this

Designer DNA Nanoarchitectures. / Lin, Chenxiang; Liu, Yan; Yan, Hao.

In: Biochemistry, Vol. 48, No. 8, 03.03.2009, p. 1663-1674.

Research output: Contribution to journalArticle

Lin, Chenxiang ; Liu, Yan ; Yan, Hao. / Designer DNA Nanoarchitectures. In: Biochemistry. 2009 ; Vol. 48, No. 8. pp. 1663-1674.
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