Designer DNA nanostructures for therapeutics

Shuoxing Jiang, Zhilei Ge, Shan Mou, Hao Yan, Chunhai Fan

Research output: Contribution to journalReview articlepeer-review

Abstract

The development of nanomedicine is closely related to the evolution of nanocarriers that endow therapeutic agents with improved efficacy, safety, and targeting specificity. A grand challenge in nanomedicine is the ability to design suitable nanocarriers that can precisely transport therapeutic agents across biological barriers in the complex environment of living organisms. The programmable and biocompatible nature of DNA has enabled the rational design of tailored DNA nanocarriers for targeted drug delivery, which has greatly contributed to the remarkable progress in cancer therapy. Additionally, DNA nanotechnology-enabled therapeutic systems have demonstrated profound potential in the development of smart therapeutic robotic systems and the treatment of renal diseases. In this review, we discuss the roles of DNA nanostructures in different therapeutic strategies and highlight model systems that hold promise for clinical translation in the long term.

Original languageEnglish
JournalChem
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • acute kidney injury
  • cancer therapeutics
  • drug delivery
  • nanocarrier
  • SDG3: Good health and well-being
  • structural DNA nanotechnology
  • therapeutic DNA nanorobot

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Environmental Chemistry
  • Chemical Engineering(all)
  • Biochemistry, medical
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Designer DNA nanostructures for therapeutics'. Together they form a unique fingerprint.

Cite this