Abstract
Infants of diabetic mothers have three to four times the incidence of congenital malformations than that in the general population. These anomalies include defects of the neural tube, heart, urogenital system, skeleton and alimentary tract, and the caudal regression syndrome. The anomalies are considered to result from the maternal metabolic derangements. The mechanism has been suggested to involve a diminished turnover of phosphoinositide or arachidonic acid, or an excess of free oxygen radicals. As most of the anomalies in infants of diabetic mothers occur in the first few weeks of pregnancy, strict glycemic control beginning before conception appears mandated.
| Original language | English |
|---|---|
| Pages (from-to) | 486-491 |
| Number of pages | 6 |
| Journal | Current Opinion in Pediatrics |
| Volume | 6 |
| Issue number | 4 |
| Publication status | Published - 1994 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Diabetic embryopathy. / Goto, M. P.; Goldman, Alan S.
In: Current Opinion in Pediatrics, Vol. 6, No. 4, 1994, p. 486-491.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diabetic embryopathy
AU - Goto, M. P.
AU - Goldman, Alan S
PY - 1994
Y1 - 1994
N2 - Infants of diabetic mothers have three to four times the incidence of congenital malformations than that in the general population. These anomalies include defects of the neural tube, heart, urogenital system, skeleton and alimentary tract, and the caudal regression syndrome. The anomalies are considered to result from the maternal metabolic derangements. The mechanism has been suggested to involve a diminished turnover of phosphoinositide or arachidonic acid, or an excess of free oxygen radicals. As most of the anomalies in infants of diabetic mothers occur in the first few weeks of pregnancy, strict glycemic control beginning before conception appears mandated.
AB - Infants of diabetic mothers have three to four times the incidence of congenital malformations than that in the general population. These anomalies include defects of the neural tube, heart, urogenital system, skeleton and alimentary tract, and the caudal regression syndrome. The anomalies are considered to result from the maternal metabolic derangements. The mechanism has been suggested to involve a diminished turnover of phosphoinositide or arachidonic acid, or an excess of free oxygen radicals. As most of the anomalies in infants of diabetic mothers occur in the first few weeks of pregnancy, strict glycemic control beginning before conception appears mandated.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027935220&partnerID=8YFLogxK
M3 - Article
C2 - 7951674
AN - SCOPUS:0027935220
VL - 6
SP - 486
EP - 491
JO - Current Opinion in Pediatrics
JF - Current Opinion in Pediatrics
SN - 1040-8703
IS - 4
ER -