Differences in the Toxicological Potential of 2D versus Aggregated Molybdenum Disulfide in the Lung

Xiang Wang, Nikhita D. Mansukhani, Linda M. Guiney, Zhaoxia Ji, Chong Hyun Chang, Meiying Wang, Yu Pei Liao, Tze Bin Song, Bingbing Sun, Ruibin Li, Tian Xia, Mark C Hersam, André E. Nel

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

2D molybdenum disulfide (MoS2) has distinct optical and electronic properties compared to aggregated MoS2, enabling wide use of these materials for electronic and biomedical applications. However, the hazard potential of MoS2 has not been studied extensively. Here, a comprehensive analysis of the pulmonary hazard potential of three aqueous suspended forms of MoS2 - aggregated MoS2 (Agg-MoS2), MoS2 exfoliated by lithiation (Lit-MoS2), and MoS2 dispersed by Pluronic F87 (PF87-MoS2) - is presented. No cytotoxicity is detected in THP-1 and BEAS-2B cell lines. However, Agg-MoS2 induces strong proinflammatory and profibrogenic responses in vitro. In contrast, Lit- and PF87-MoS2 have little or no effect. In an acute toxicity study in mice, Agg-MoS2 induces acute lung inflammation, while Lit-MoS2 and PF87-MoS2 have little or no effect. In a subchronic study, there is no evidence of pulmonary fibrosis in response to all forms of MoS2. These data suggest that exfoliation attenuates the toxicity of Agg-MoS2, which is an important consideration toward the safety evaluation and use of nanoscale MoS2 materials for industrial and biological applications. The pulmonary hazard potential of three forms of MoS2 - aggregated (Agg-MoS2), lithiation-exfoliated (Lit-MoS2), and Pluronic F87 dispersed MoS2 (PF87-MoS2) - is studied. Although Agg-MoS2 induces profibrogenic responses in vitro and acute lung inflammation in vivo, Lit- and PF87-MoS2 have no such effect. These data suggest that exfoliation attenuates Agg-MoS2's toxicity, which is important toward its industrial and biological applications.

Original languageEnglish
Pages (from-to)5079-5087
Number of pages9
JournalSmall
Volume11
Issue number38
DOIs
Publication statusPublished - Oct 1 2015

Fingerprint

Poloxamer
Toxicology
Molybdenum
Toxicity
Hazards
Lung
Cytotoxicity
Electronic properties
Pneumonia
Optical properties
Cells
Pulmonary Fibrosis
molybdenum disulfide
Safety
Cell Line

Keywords

  • cytotoxicity
  • hazard assessment
  • molybdenum disulfide
  • pulmonary toxicity

ASJC Scopus subject areas

  • Biomaterials
  • Engineering (miscellaneous)
  • Biotechnology

Cite this

Wang, X., Mansukhani, N. D., Guiney, L. M., Ji, Z., Chang, C. H., Wang, M., ... Nel, A. E. (2015). Differences in the Toxicological Potential of 2D versus Aggregated Molybdenum Disulfide in the Lung. Small, 11(38), 5079-5087. https://doi.org/10.1002/smll.201500906

Differences in the Toxicological Potential of 2D versus Aggregated Molybdenum Disulfide in the Lung. / Wang, Xiang; Mansukhani, Nikhita D.; Guiney, Linda M.; Ji, Zhaoxia; Chang, Chong Hyun; Wang, Meiying; Liao, Yu Pei; Song, Tze Bin; Sun, Bingbing; Li, Ruibin; Xia, Tian; Hersam, Mark C; Nel, André E.

In: Small, Vol. 11, No. 38, 01.10.2015, p. 5079-5087.

Research output: Contribution to journalArticle

Wang, X, Mansukhani, ND, Guiney, LM, Ji, Z, Chang, CH, Wang, M, Liao, YP, Song, TB, Sun, B, Li, R, Xia, T, Hersam, MC & Nel, AE 2015, 'Differences in the Toxicological Potential of 2D versus Aggregated Molybdenum Disulfide in the Lung', Small, vol. 11, no. 38, pp. 5079-5087. https://doi.org/10.1002/smll.201500906
Wang X, Mansukhani ND, Guiney LM, Ji Z, Chang CH, Wang M et al. Differences in the Toxicological Potential of 2D versus Aggregated Molybdenum Disulfide in the Lung. Small. 2015 Oct 1;11(38):5079-5087. https://doi.org/10.1002/smll.201500906
Wang, Xiang ; Mansukhani, Nikhita D. ; Guiney, Linda M. ; Ji, Zhaoxia ; Chang, Chong Hyun ; Wang, Meiying ; Liao, Yu Pei ; Song, Tze Bin ; Sun, Bingbing ; Li, Ruibin ; Xia, Tian ; Hersam, Mark C ; Nel, André E. / Differences in the Toxicological Potential of 2D versus Aggregated Molybdenum Disulfide in the Lung. In: Small. 2015 ; Vol. 11, No. 38. pp. 5079-5087.
@article{0c1912b57f1e4982afa0cb7b7ae89dcc,
title = "Differences in the Toxicological Potential of 2D versus Aggregated Molybdenum Disulfide in the Lung",
abstract = "2D molybdenum disulfide (MoS2) has distinct optical and electronic properties compared to aggregated MoS2, enabling wide use of these materials for electronic and biomedical applications. However, the hazard potential of MoS2 has not been studied extensively. Here, a comprehensive analysis of the pulmonary hazard potential of three aqueous suspended forms of MoS2 - aggregated MoS2 (Agg-MoS2), MoS2 exfoliated by lithiation (Lit-MoS2), and MoS2 dispersed by Pluronic F87 (PF87-MoS2) - is presented. No cytotoxicity is detected in THP-1 and BEAS-2B cell lines. However, Agg-MoS2 induces strong proinflammatory and profibrogenic responses in vitro. In contrast, Lit- and PF87-MoS2 have little or no effect. In an acute toxicity study in mice, Agg-MoS2 induces acute lung inflammation, while Lit-MoS2 and PF87-MoS2 have little or no effect. In a subchronic study, there is no evidence of pulmonary fibrosis in response to all forms of MoS2. These data suggest that exfoliation attenuates the toxicity of Agg-MoS2, which is an important consideration toward the safety evaluation and use of nanoscale MoS2 materials for industrial and biological applications. The pulmonary hazard potential of three forms of MoS2 - aggregated (Agg-MoS2), lithiation-exfoliated (Lit-MoS2), and Pluronic F87 dispersed MoS2 (PF87-MoS2) - is studied. Although Agg-MoS2 induces profibrogenic responses in vitro and acute lung inflammation in vivo, Lit- and PF87-MoS2 have no such effect. These data suggest that exfoliation attenuates Agg-MoS2's toxicity, which is important toward its industrial and biological applications.",
keywords = "cytotoxicity, hazard assessment, molybdenum disulfide, pulmonary toxicity",
author = "Xiang Wang and Mansukhani, {Nikhita D.} and Guiney, {Linda M.} and Zhaoxia Ji and Chang, {Chong Hyun} and Meiying Wang and Liao, {Yu Pei} and Song, {Tze Bin} and Bingbing Sun and Ruibin Li and Tian Xia and Hersam, {Mark C} and Nel, {Andr{\'e} E.}",
year = "2015",
month = "10",
day = "1",
doi = "10.1002/smll.201500906",
language = "English",
volume = "11",
pages = "5079--5087",
journal = "Small",
issn = "1613-6810",
publisher = "Wiley-VCH Verlag",
number = "38",

}

TY - JOUR

T1 - Differences in the Toxicological Potential of 2D versus Aggregated Molybdenum Disulfide in the Lung

AU - Wang, Xiang

AU - Mansukhani, Nikhita D.

AU - Guiney, Linda M.

AU - Ji, Zhaoxia

AU - Chang, Chong Hyun

AU - Wang, Meiying

AU - Liao, Yu Pei

AU - Song, Tze Bin

AU - Sun, Bingbing

AU - Li, Ruibin

AU - Xia, Tian

AU - Hersam, Mark C

AU - Nel, André E.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - 2D molybdenum disulfide (MoS2) has distinct optical and electronic properties compared to aggregated MoS2, enabling wide use of these materials for electronic and biomedical applications. However, the hazard potential of MoS2 has not been studied extensively. Here, a comprehensive analysis of the pulmonary hazard potential of three aqueous suspended forms of MoS2 - aggregated MoS2 (Agg-MoS2), MoS2 exfoliated by lithiation (Lit-MoS2), and MoS2 dispersed by Pluronic F87 (PF87-MoS2) - is presented. No cytotoxicity is detected in THP-1 and BEAS-2B cell lines. However, Agg-MoS2 induces strong proinflammatory and profibrogenic responses in vitro. In contrast, Lit- and PF87-MoS2 have little or no effect. In an acute toxicity study in mice, Agg-MoS2 induces acute lung inflammation, while Lit-MoS2 and PF87-MoS2 have little or no effect. In a subchronic study, there is no evidence of pulmonary fibrosis in response to all forms of MoS2. These data suggest that exfoliation attenuates the toxicity of Agg-MoS2, which is an important consideration toward the safety evaluation and use of nanoscale MoS2 materials for industrial and biological applications. The pulmonary hazard potential of three forms of MoS2 - aggregated (Agg-MoS2), lithiation-exfoliated (Lit-MoS2), and Pluronic F87 dispersed MoS2 (PF87-MoS2) - is studied. Although Agg-MoS2 induces profibrogenic responses in vitro and acute lung inflammation in vivo, Lit- and PF87-MoS2 have no such effect. These data suggest that exfoliation attenuates Agg-MoS2's toxicity, which is important toward its industrial and biological applications.

AB - 2D molybdenum disulfide (MoS2) has distinct optical and electronic properties compared to aggregated MoS2, enabling wide use of these materials for electronic and biomedical applications. However, the hazard potential of MoS2 has not been studied extensively. Here, a comprehensive analysis of the pulmonary hazard potential of three aqueous suspended forms of MoS2 - aggregated MoS2 (Agg-MoS2), MoS2 exfoliated by lithiation (Lit-MoS2), and MoS2 dispersed by Pluronic F87 (PF87-MoS2) - is presented. No cytotoxicity is detected in THP-1 and BEAS-2B cell lines. However, Agg-MoS2 induces strong proinflammatory and profibrogenic responses in vitro. In contrast, Lit- and PF87-MoS2 have little or no effect. In an acute toxicity study in mice, Agg-MoS2 induces acute lung inflammation, while Lit-MoS2 and PF87-MoS2 have little or no effect. In a subchronic study, there is no evidence of pulmonary fibrosis in response to all forms of MoS2. These data suggest that exfoliation attenuates the toxicity of Agg-MoS2, which is an important consideration toward the safety evaluation and use of nanoscale MoS2 materials for industrial and biological applications. The pulmonary hazard potential of three forms of MoS2 - aggregated (Agg-MoS2), lithiation-exfoliated (Lit-MoS2), and Pluronic F87 dispersed MoS2 (PF87-MoS2) - is studied. Although Agg-MoS2 induces profibrogenic responses in vitro and acute lung inflammation in vivo, Lit- and PF87-MoS2 have no such effect. These data suggest that exfoliation attenuates Agg-MoS2's toxicity, which is important toward its industrial and biological applications.

KW - cytotoxicity

KW - hazard assessment

KW - molybdenum disulfide

KW - pulmonary toxicity

UR - http://www.scopus.com/inward/record.url?scp=84943585897&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943585897&partnerID=8YFLogxK

U2 - 10.1002/smll.201500906

DO - 10.1002/smll.201500906

M3 - Article

VL - 11

SP - 5079

EP - 5087

JO - Small

JF - Small

SN - 1613-6810

IS - 38

ER -