Dip-pen patterning and surface assembly of peptide amphiphiles

Hongzhou Jiang, Samuel I. Stupp

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


This paper presents results on controlling the surface morphology of evaporation-driven self-assembly of peptide amphiphile (PA) nanofibers by dip-pen nanolithography. These PA nanofibers, which measure only a few nanometers in diameter, can be oriented perpendicularly to the receding edge of a solution. Dragging a meniscus of PA ink with an atomic force microscope (AFM) tip creates reproducibly aligned arrays of isolated and close-packed PA nanofiber patterns on silicon substrates, utilizing surface coating of poly(ethylene glycol) to suppress the self-assembly of nanofibers on AFM tips. We also demonstrate the ability to construct double-layer patterns of differing nanofiber orientations at the same position. This result could be important in producing a complex, multilayer pattern of these peptide-based supramolecular nanostructures.

Original languageEnglish
Pages (from-to)5242-5246
Number of pages5
Issue number12
Publication statusPublished - Jun 7 2005

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

Fingerprint Dive into the research topics of 'Dip-pen patterning and surface assembly of peptide amphiphiles'. Together they form a unique fingerprint.

Cite this