Direct Conversion of Alcohols into Alkenes by Dehydrogenative Coupling with Hydrazine/Hydrazone Catalyzed by Manganese

Uttam Kumar Das, Subrata Chakraborty, Yael Diskin-Posner, David Milstein

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We have developed unprecedented methods for the direct transformation of primary alcohols to alkenes in the presence of hydrazine, and for the synthesis of mixed alkenes by the reaction of alcohols with hydrazones. The reactions are catalyzed by a manganese pincer complex and proceed in absence of added base or hydrogen acceptors, liberating dihydrogen, dinitrogen, and water as the only byproducts. The proposed mechanism, based on preparation of proposed intermediates and control experiments, suggests that the transformation occurs through metal–ligand cooperative N−H activation of a hydrazone intermediate.

Original languageEnglish
Pages (from-to)13444-13448
Number of pages5
JournalAngewandte Chemie - International Edition
Volume57
Issue number41
DOIs
Publication statusPublished - Oct 8 2018

Keywords

  • alcohols
  • dehydrogenative coupling
  • homogeneous catalysis
  • hydrazines
  • manganese

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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