Direct deamination of primary amines by water to produce alcohols

Julia R. Khusnutdinova, Yehoshoa Ben-David, David Milstein

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Just add water! The title reaction is catalyzed by an acridine-based pincer complex (1, see scheme). This one-step transformation uses water as the only reagent in the absence of additional bases, oxidants, or reductants. Cyclization of 1,4-diaminobutane and 1,6-diaminohexane catalyzed by 1 leads to the formation of pyrrolidine and azepane, respectively.

Original languageEnglish
Pages (from-to)6269-6272
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number24
DOIs
Publication statusPublished - Jun 10 2013

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1,6-diaminohexane
Amines
Alcohols
Acridines
Putrescine
Water
Cyclization
Reducing Agents
Oxidants
pyrrolidine

Keywords

  • alcohols
  • amines
  • pincer ligands
  • ruthenium
  • water

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Direct deamination of primary amines by water to produce alcohols. / Khusnutdinova, Julia R.; Ben-David, Yehoshoa; Milstein, David.

In: Angewandte Chemie - International Edition, Vol. 52, No. 24, 10.06.2013, p. 6269-6272.

Research output: Contribution to journalArticle

Khusnutdinova, Julia R. ; Ben-David, Yehoshoa ; Milstein, David. / Direct deamination of primary amines by water to produce alcohols. In: Angewandte Chemie - International Edition. 2013 ; Vol. 52, No. 24. pp. 6269-6272.
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