Direct deamination of primary amines by water to produce alcohols

Julia R. Khusnutdinova, Yehoshoa Ben-David, David Milstein

Research output: Contribution to journalReview article

19 Citations (Scopus)


Just add water! The title reaction is catalyzed by an acridine-based pincer complex (1, see scheme). This one-step transformation uses water as the only reagent in the absence of additional bases, oxidants, or reductants. Cyclization of 1,4-diaminobutane and 1,6-diaminohexane catalyzed by 1 leads to the formation of pyrrolidine and azepane, respectively.

Original languageEnglish
Pages (from-to)6269-6272
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number24
Publication statusPublished - Jun 10 2013



  • alcohols
  • amines
  • pincer ligands
  • ruthenium
  • water

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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