Direct measurement of the dynamics of hole hopping in extended DNA G-tracts. an unbiased random walk

Sarah M.Mickley Conron, Arun K. Thazhathveetil, Michael R. Wasielewski, Alexander L. Burin, Frederick D. Lewis

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

We report the measurement of distance- and temperature-dependent rate constants for charge separation in capped hairpins in which a stilbene hole acceptor and hole donor are separated by A3Gn diblock polypurine sequences consisting of 3 adenines and 1-19 guanines. The longer diblock systems obey the simplest model for an unbiased random walk, providing a direct measurement of khop = 4.3 × 109 s -1 for a single reversible G-to-G hole hopping step, somewhat faster than the value of 1.2 × 109 s-1 calculated for A-tract hole hopping. The temperature dependence for hopping in A 3G13 provides values of Eact = 2.8 kcal/mol and A = 7 × 109 s-1, consistent with a weakly activated, conformationally gated process.

Original languageEnglish
Pages (from-to)14388-14390
Number of pages3
JournalJournal of the American Chemical Society
Volume132
Issue number41
DOIs
Publication statusPublished - Oct 20 2010

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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