Abstract
We report the measurement of distance- and temperature-dependent rate constants for charge separation in capped hairpins in which a stilbene hole acceptor and hole donor are separated by A3Gn diblock polypurine sequences consisting of 3 adenines and 1-19 guanines. The longer diblock systems obey the simplest model for an unbiased random walk, providing a direct measurement of khop = 4.3 × 109 s -1 for a single reversible G-to-G hole hopping step, somewhat faster than the value of 1.2 × 109 s-1 calculated for A-tract hole hopping. The temperature dependence for hopping in A 3G13 provides values of Eact = 2.8 kcal/mol and A = 7 × 109 s-1, consistent with a weakly activated, conformationally gated process.
| Original language | English |
|---|---|
| Pages (from-to) | 14388-14390 |
| Number of pages | 3 |
| Journal | Journal of the American Chemical Society |
| Volume | 132 |
| Issue number | 41 |
| DOIs | |
| Publication status | Published - Oct 20 2010 |
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ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
- Biochemistry
- Colloid and Surface Chemistry
Cite this
Direct measurement of the dynamics of hole hopping in extended DNA G-tracts. an unbiased random walk. / Conron, Sarah M Mickley; Thazhathveetil, Arun K.; Wasielewski, Michael R; Burin, Alexander L.; Lewis, Frederick D.
In: Journal of the American Chemical Society, Vol. 132, No. 41, 20.10.2010, p. 14388-14390.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Direct measurement of the dynamics of hole hopping in extended DNA G-tracts. an unbiased random walk
AU - Conron, Sarah M Mickley
AU - Thazhathveetil, Arun K.
AU - Wasielewski, Michael R
AU - Burin, Alexander L.
AU - Lewis, Frederick D.
PY - 2010/10/20
Y1 - 2010/10/20
N2 - We report the measurement of distance- and temperature-dependent rate constants for charge separation in capped hairpins in which a stilbene hole acceptor and hole donor are separated by A3Gn diblock polypurine sequences consisting of 3 adenines and 1-19 guanines. The longer diblock systems obey the simplest model for an unbiased random walk, providing a direct measurement of khop = 4.3 × 109 s -1 for a single reversible G-to-G hole hopping step, somewhat faster than the value of 1.2 × 109 s-1 calculated for A-tract hole hopping. The temperature dependence for hopping in A 3G13 provides values of Eact = 2.8 kcal/mol and A = 7 × 109 s-1, consistent with a weakly activated, conformationally gated process.
AB - We report the measurement of distance- and temperature-dependent rate constants for charge separation in capped hairpins in which a stilbene hole acceptor and hole donor are separated by A3Gn diblock polypurine sequences consisting of 3 adenines and 1-19 guanines. The longer diblock systems obey the simplest model for an unbiased random walk, providing a direct measurement of khop = 4.3 × 109 s -1 for a single reversible G-to-G hole hopping step, somewhat faster than the value of 1.2 × 109 s-1 calculated for A-tract hole hopping. The temperature dependence for hopping in A 3G13 provides values of Eact = 2.8 kcal/mol and A = 7 × 109 s-1, consistent with a weakly activated, conformationally gated process.
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U2 - 10.1021/ja106991f
DO - 10.1021/ja106991f
M3 - Article
VL - 132
SP - 14388
EP - 14390
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 41
ER -