Direct observation of morphological tranformation from twisted ribbons into helical ribbons

E. Thomas Pashuck, Samuel I Stupp

Research output: Contribution to journalArticle

190 Citations (Scopus)

Abstract

We report on the direct observation of a nanostructural transformation from a twisted ribbon to a helical ribbon in supramolecular assemblies of peptide amphiphiles. Using cryogenic electron microscopy, a peptide amphiphile molecule containing aromatic residues was found to first assemble into short twisted ribbons in the time range of seconds, which then elongate in the time scale of minutes, and finally transform into helical ribbons over the course of weeks. By synthesizing an analogous molecule without the aromatic side groups, it was found that a cylindrical nanostructure is formed that does not undergo any transitions during the same time period. The study of metastable states in peptide aggregation can contribute to our understanding of amyloid-related diseases, such as Alzheimers disease.

Original languageEnglish
Pages (from-to)8819-8821
Number of pages3
JournalJournal of the American Chemical Society
Volume132
Issue number26
DOIs
Publication statusPublished - Jul 7 2010

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Peptides
Amphiphiles
Observation
Molecules
Nanostructures
Amyloid
Cryogenics
Electron microscopy
Electron Microscopy
Alzheimer Disease
Agglomeration

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry
  • Medicine(all)

Cite this

Direct observation of morphological tranformation from twisted ribbons into helical ribbons. / Pashuck, E. Thomas; Stupp, Samuel I.

In: Journal of the American Chemical Society, Vol. 132, No. 26, 07.07.2010, p. 8819-8821.

Research output: Contribution to journalArticle

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