Direct Synthesis of Amides by Dehydrogenative Coupling of Amines with either Alcohols or Esters: Manganese Pincer Complex as Catalyst

Amit Kumar, Noel Angel Espinosa-Jalapa, Gregory Leitus, Yael Diskin-Posner, Liat Avram, David Milstein

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60 Citations (Scopus)


The first example of base-metal-catalysed synthesis of amides from the coupling of primary amines with either alcohols or esters is reported. The reactions are catalysed by a new manganese pincer complex and generate hydrogen gas as the sole byproduct, thus making the overall process atom-economical and sustainable.

Original languageEnglish
Pages (from-to)14992-14996
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number47
Publication statusPublished - Nov 20 2017



  • amides
  • amines
  • ligand design
  • manganese
  • structure elucidation

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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