Direct Synthesis of Amides by Dehydrogenative Coupling of Amines with either Alcohols or Esters

Manganese Pincer Complex as Catalyst

Amit Kumar, Noel Angel Espinosa-Jalapa, Gregory Leitus, Yael Diskin-Posner, Liat Avram, David Milstein

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The first example of base-metal-catalysed synthesis of amides from the coupling of primary amines with either alcohols or esters is reported. The reactions are catalysed by a new manganese pincer complex and generate hydrogen gas as the sole byproduct, thus making the overall process atom-economical and sustainable.

Original languageEnglish
Pages (from-to)14992-14996
Number of pages5
JournalAngewandte Chemie - International Edition
Volume56
Issue number47
DOIs
Publication statusPublished - Nov 20 2017

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Manganese
Amides
Amines
Byproducts
Hydrogen
Esters
Alcohols
Gases
Metals
Atoms
Catalysts

Keywords

  • amides
  • amines
  • ligand design
  • manganese
  • structure elucidation

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Direct Synthesis of Amides by Dehydrogenative Coupling of Amines with either Alcohols or Esters : Manganese Pincer Complex as Catalyst. / Kumar, Amit; Espinosa-Jalapa, Noel Angel; Leitus, Gregory; Diskin-Posner, Yael; Avram, Liat; Milstein, David.

In: Angewandte Chemie - International Edition, Vol. 56, No. 47, 20.11.2017, p. 14992-14996.

Research output: Contribution to journalArticle

Kumar, Amit ; Espinosa-Jalapa, Noel Angel ; Leitus, Gregory ; Diskin-Posner, Yael ; Avram, Liat ; Milstein, David. / Direct Synthesis of Amides by Dehydrogenative Coupling of Amines with either Alcohols or Esters : Manganese Pincer Complex as Catalyst. In: Angewandte Chemie - International Edition. 2017 ; Vol. 56, No. 47. pp. 14992-14996.
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