Direct Synthesis of Benzimidazoles by Dehydrogenative Coupling of Aromatic Diamines and Alcohols Catalyzed by Cobalt

Prosenjit Daw; Yehoshoa Ben-David; David Milstein

doi:10.1021/acscatal.7b02777

Direct Synthesis of Benzimidazoles by Dehydrogenative Coupling of Aromatic Diamines and Alcohols Catalyzed by Cobalt

Prosenjit Daw, Yehoshoa Ben-David, David Milstein

Weizmann Institute of Science, Israel

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

Herein, we present the base-metal-catalyzed dehydrogenative coupling of primary alcohols and aromatic diamines to selectively form functionalized 2-substituted benzimidazoles, liberating water and hydrogen gas as the sole byproducts. The reaction is catalyzed by pincer complexes of Earth-abundant cobalt under base-free conditions.

Original language	English
Pages (from-to)	7456-7460
Number of pages	5
Journal	ACS Catalysis
Volume	7
Issue number	11
DOIs	https://doi.org/10.1021/acscatal.7b02777
Publication status	Published - Nov 3 2017

Keywords

Alcohol
Benzimidazole
Cobalt
Dehydrogenative Coupling
Pincer

ASJC Scopus subject areas

Catalysis

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10.1021/acscatal.7b02777

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AB - Herein, we present the base-metal-catalyzed dehydrogenative coupling of primary alcohols and aromatic diamines to selectively form functionalized 2-substituted benzimidazoles, liberating water and hydrogen gas as the sole byproducts. The reaction is catalyzed by pincer complexes of Earth-abundant cobalt under base-free conditions.

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KW - Pincer

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