Direct synthesis of imines from alcohols and amines with liberation of H2

Boopathy Gnanaprakasam, Jing Zhang, David Milstein

Research output: Contribution to journalArticle

341 Citations (Scopus)

Abstract

"Chemical equation presented" A clean sweep: Aryl and aliphatic mines can be synthesized directly and efficiently from alcohols and amines under mild, neutral conditions with the liberation of only molecular hydrogen and water (see scheme; R=isopropyl, tert-butyl). This general, environmentally benign reaction is catalyzed by a de-aromatized ruthenium PNP pincer complex (0.2 mol%), and can proceed in toluene under an inert atmosphere or under air.

Original languageEnglish
Pages (from-to)1468-1471
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number8
DOIs
Publication statusPublished - Feb 15 2010

Keywords

  • Homogeneous catalysis
  • Mines
  • Pincer complexes
  • Ruthenium
  • Synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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