Direct synthesis of imines from alcohols and amines with liberation of H2

Boopathy Gnanaprakasam; Jing Zhang; David Milstein

doi:10.1002/anie.200907018

Direct synthesis of imines from alcohols and amines with liberation of H2

Boopathy Gnanaprakasam, Jing Zhang, David Milstein

Weizmann Institute of Science, Israel

Research output: Contribution to journal › Article › peer-review

341 Citations (Scopus)

Abstract

"Chemical equation presented" A clean sweep: Aryl and aliphatic mines can be synthesized directly and efficiently from alcohols and amines under mild, neutral conditions with the liberation of only molecular hydrogen and water (see scheme; R=isopropyl, tert-butyl). This general, environmentally benign reaction is catalyzed by a de-aromatized ruthenium PNP pincer complex (0.2 mol%), and can proceed in toluene under an inert atmosphere or under air.

Original language	English
Pages (from-to)	1468-1471
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	8
DOIs	https://doi.org/10.1002/anie.200907018
Publication status	Published - Feb 15 2010

Keywords

Homogeneous catalysis
Mines
Pincer complexes
Ruthenium
Synthetic methods

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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AU - Milstein, David

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KW - Synthetic methods

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