Direct synthesis of pyrroles by dehydrogenative coupling of β-aminoalcohols with secondary alcohols catalyzed by ruthenium pincer complexes

Dipankar Srimani, Yehoshoa Ben-David, David Milstein

Research output: Contribution to journalArticle

194 Citations (Scopus)

Abstract

Pyrroles were synthesized in one step by using the acceptorless dehydrogenative coupling of amino alcohols with secondary alcohols (equivalent amounts), catalyzed by ruthenium pincer complexes (0.5 mol %) and a base (less than stoichiometric amounts) through selective C-N and C-C bond formation. This atom-economical, environmentally friendly methodology offers easy access to a range of substituted pyrroles in moderate to good yields.

Original languageEnglish
Pages (from-to)4012-4015
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number14
DOIs
Publication statusPublished - Apr 2 2013

Fingerprint

Amino alcohols
Pyrroles
Ruthenium
Alcohols
Amino Alcohols
Atoms

Keywords

  • dehydrogenation
  • homogeneous catalysis
  • pincer complex
  • pyrroles
  • ruthenium

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Direct synthesis of pyrroles by dehydrogenative coupling of β-aminoalcohols with secondary alcohols catalyzed by ruthenium pincer complexes. / Srimani, Dipankar; Ben-David, Yehoshoa; Milstein, David.

In: Angewandte Chemie - International Edition, Vol. 52, No. 14, 02.04.2013, p. 4012-4015.

Research output: Contribution to journalArticle

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