Direct synthesis of pyrroles by dehydrogenative coupling of β-aminoalcohols with secondary alcohols catalyzed by ruthenium pincer complexes

Dipankar Srimani, Yehoshoa Ben-David, David Milstein

Research output: Contribution to journalArticle

199 Citations (Scopus)


Pyrroles were synthesized in one step by using the acceptorless dehydrogenative coupling of amino alcohols with secondary alcohols (equivalent amounts), catalyzed by ruthenium pincer complexes (0.5 mol %) and a base (less than stoichiometric amounts) through selective C-N and C-C bond formation. This atom-economical, environmentally friendly methodology offers easy access to a range of substituted pyrroles in moderate to good yields.

Original languageEnglish
Pages (from-to)4012-4015
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number14
Publication statusPublished - Apr 2 2013



  • dehydrogenation
  • homogeneous catalysis
  • pincer complex
  • pyrroles
  • ruthenium

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this