DNA gridiron nanostructures based on four-arm junctions

Dongran Han, Suchetan Pal, Yang Yang, Shuoxing Jiang, Jeanette Nangreave, Yan Liu, Hao Yan

Research output: Contribution to journalArticle

153 Citations (Scopus)

Abstract

Engineering wireframe architectures and scaffolds of increasing complexity is one of the important challenges in nanotechnology. We present a design strategy to create gridiron-like DNA structures. A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons were assembled, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects.

Original languageEnglish
Pages (from-to)1412-1415
Number of pages4
JournalScience
Volume339
Issue number6126
DOIs
Publication statusPublished - Mar 22 2013

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Cite this

Han, D., Pal, S., Yang, Y., Jiang, S., Nangreave, J., Liu, Y., & Yan, H. (2013). DNA gridiron nanostructures based on four-arm junctions. Science, 339(6126), 1412-1415. https://doi.org/10.1126/science.1232252