DNA-Templated Self-Assembly of Protein and Nanoparticle Linear Arrays

Hanying Li, Sung Ha Park, John H. Reif, Thomas H. LaBean, Hao Yan

Research output: Contribution to journalArticle

256 Citations (Scopus)

Abstract

Self-assembling DNA tiling lattices represent a versatile system for nanoscale construction. Self-assembled DNA arrays provide an excellent template for spatially positioning other molecules with increased relative precision and programmability. Here we report an experiment using a linear array of DNA triple crossover tiles to controllably template the self-assembly of single-layer or double-layer linear arrays of streptavidin molecules and streptavidin-conjugated nanogold particles through biotin-streptavidin interaction. The organization of streptavidin and its conjugated gold nanoparticles into periodic arrays was visualized by atomic force microscopy and scanning electron microscopy.

Original languageEnglish
Pages (from-to)418-419
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number2
DOIs
Publication statusPublished - Jan 21 2004

Fingerprint

Streptavidin
Nanoparticles
Self assembly
DNA
Proteins
Oligonucleotide Array Sequence Analysis
Molecules
Tile
Atomic Force Microscopy
Atomic force microscopy
Biotin
Gold
Electron Scanning Microscopy
Scanning electron microscopy
Experiments

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

DNA-Templated Self-Assembly of Protein and Nanoparticle Linear Arrays. / Li, Hanying; Park, Sung Ha; Reif, John H.; LaBean, Thomas H.; Yan, Hao.

In: Journal of the American Chemical Society, Vol. 126, No. 2, 21.01.2004, p. 418-419.

Research output: Contribution to journalArticle

Li, Hanying ; Park, Sung Ha ; Reif, John H. ; LaBean, Thomas H. ; Yan, Hao. / DNA-Templated Self-Assembly of Protein and Nanoparticle Linear Arrays. In: Journal of the American Chemical Society. 2004 ; Vol. 126, No. 2. pp. 418-419.
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