Abstract
Hydrolytically-labile hydrazones in peptide amphiphiles were studied as degradable tethers for release of the drug nabumetone from nanofiber gels. On-resin addition of the novel compound tri-Boc-hydrazido adipic acid to a lysine ε-amine allowed for precise placement of a hydrazide in a peptide sequence.
| Original language | English |
|---|---|
| Pages (from-to) | 7962-7964 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Volume | 47 |
| Issue number | 28 |
| DOIs | |
| Publication status | Published - Jul 28 2011 |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
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Cite this
Matson, J. B., & Stupp, S. I. (2011). Drug release from hydrazone-containing peptide amphiphiles. Chemical Communications, 47(28), 7962-7964. https://doi.org/10.1039/c1cc12570b