Drug release from hydrazone-containing peptide amphiphiles

John B. Matson, Samuel I Stupp

Research output: Contribution to journal › Article

84 Citations (Scopus)

Abstract

Hydrolytically-labile hydrazones in peptide amphiphiles were studied as degradable tethers for release of the drug nabumetone from nanofiber gels. On-resin addition of the novel compound tri-Boc-hydrazido adipic acid to a lysine ε-amine allowed for precise placement of a hydrazide in a peptide sequence.

Original languageEnglish
Pages (from-to)7962-7964
Number of pages3
JournalChemical Communications
Volume47
Issue number28
DOIs
Publication statusPublished - Jul 28 2011

Fingerprint

Hydrazones
Amphiphiles
nabumetone
Peptides
Nanofibers
Pharmaceutical Preparations
Lysine
Amines
Gels
Resins
Acids
adipic acid

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Drug release from hydrazone-containing peptide amphiphiles. / Matson, John B.; Stupp, Samuel I.

In: Chemical Communications, Vol. 47, No. 28, 28.07.2011, p. 7962-7964.

Research output: Contribution to journal › Article

Matson, JB & Stupp, SI 2011, 'Drug release from hydrazone-containing peptide amphiphiles', Chemical Communications, vol. 47, no. 28, pp. 7962-7964. https://doi.org/10.1039/c1cc12570b
Matson JB, Stupp SI. Drug release from hydrazone-containing peptide amphiphiles. Chemical Communications. 2011 Jul 28;47(28):7962-7964. https://doi.org/10.1039/c1cc12570b
Matson, John B. ; Stupp, Samuel I. / Drug release from hydrazone-containing peptide amphiphiles. In: Chemical Communications. 2011 ; Vol. 47, No. 28. pp. 7962-7964.
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