Drug release from hydrazone-containing peptide amphiphiles

John B. Matson, Samuel I Stupp

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Hydrolytically-labile hydrazones in peptide amphiphiles were studied as degradable tethers for release of the drug nabumetone from nanofiber gels. On-resin addition of the novel compound tri-Boc-hydrazido adipic acid to a lysine ε-amine allowed for precise placement of a hydrazide in a peptide sequence.

Original languageEnglish
Pages (from-to)7962-7964
Number of pages3
JournalChemical Communications
Volume47
Issue number28
DOIs
Publication statusPublished - Jul 28 2011

Fingerprint

Hydrazones
Amphiphiles
nabumetone
Peptides
Nanofibers
Pharmaceutical Preparations
Lysine
Amines
Gels
Resins
Acids
adipic acid

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Drug release from hydrazone-containing peptide amphiphiles. / Matson, John B.; Stupp, Samuel I.

In: Chemical Communications, Vol. 47, No. 28, 28.07.2011, p. 7962-7964.

Research output: Contribution to journalArticle

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