Abstract
Hydrolytically-labile hydrazones in peptide amphiphiles were studied as degradable tethers for release of the drug nabumetone from nanofiber gels. On-resin addition of the novel compound tri-Boc-hydrazido adipic acid to a lysine ε-amine allowed for precise placement of a hydrazide in a peptide sequence.
| Original language | English |
|---|---|
| Pages (from-to) | 7962-7964 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Volume | 47 |
| Issue number | 28 |
| DOIs | |
| Publication status | Published - Jul 28 2011 |
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ASJC Scopus subject areas
- Metals and Alloys
- Materials Chemistry
- Surfaces, Coatings and Films
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Catalysis
- Chemistry(all)
Cite this
Drug release from hydrazone-containing peptide amphiphiles. / Matson, John B.; Stupp, Samuel I.
In: Chemical Communications, Vol. 47, No. 28, 28.07.2011, p. 7962-7964.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Drug release from hydrazone-containing peptide amphiphiles
AU - Matson, John B.
AU - Stupp, Samuel I
PY - 2011/7/28
Y1 - 2011/7/28
N2 - Hydrolytically-labile hydrazones in peptide amphiphiles were studied as degradable tethers for release of the drug nabumetone from nanofiber gels. On-resin addition of the novel compound tri-Boc-hydrazido adipic acid to a lysine ε-amine allowed for precise placement of a hydrazide in a peptide sequence.
AB - Hydrolytically-labile hydrazones in peptide amphiphiles were studied as degradable tethers for release of the drug nabumetone from nanofiber gels. On-resin addition of the novel compound tri-Boc-hydrazido adipic acid to a lysine ε-amine allowed for precise placement of a hydrazide in a peptide sequence.
UR - http://www.scopus.com/inward/record.url?scp=79959869911&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79959869911&partnerID=8YFLogxK
U2 - 10.1039/c1cc12570b
DO - 10.1039/c1cc12570b
M3 - Article
C2 - 21674107
AN - SCOPUS:79959869911
VL - 47
SP - 7962
EP - 7964
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 28
ER -