Drug release from hydrazone-containing peptide amphiphiles

John B. Matson; Samuel I. Stupp

doi:10.1039/c1cc12570b

Drug release from hydrazone-containing peptide amphiphiles

John B. Matson, Samuel I. Stupp

Northwestern University

Research output: Contribution to journal › Article › peer-review

95 Citations (Scopus)

Abstract

Hydrolytically-labile hydrazones in peptide amphiphiles were studied as degradable tethers for release of the drug nabumetone from nanofiber gels. On-resin addition of the novel compound tri-Boc-hydrazido adipic acid to a lysine ε-amine allowed for precise placement of a hydrazide in a peptide sequence.

Original language	English
Pages (from-to)	7962-7964
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	28
DOIs	https://doi.org/10.1039/c1cc12570b
Publication status	Published - Jul 28 2011

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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