Dynamic display of bioactivity through host-guest chemistry

Job Boekhoven, Charles M. Rubertpérez, Shantanu Sur, Amanda Worthy, Samuel I Stupp

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

A molecular host, β-cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS-containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non-spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non-bioactive sequence RGES.

Original languageEnglish
Pages (from-to)12077-12080
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number46
DOIs
Publication statusPublished - Nov 11 2013

Fingerprint

Bioactivity
Alginate
Display devices
Molecules
Focal Adhesions
Cyclodextrins
Bearings (structural)
Cues
Culture Media
Fibroblasts
Adhesion
alginic acid

Keywords

  • biological signaling
  • cell adhesion
  • dynamics
  • host-guest chemistry
  • supramolecular chemistry

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Medicine(all)

Cite this

Dynamic display of bioactivity through host-guest chemistry. / Boekhoven, Job; Rubertpérez, Charles M.; Sur, Shantanu; Worthy, Amanda; Stupp, Samuel I.

In: Angewandte Chemie - International Edition, Vol. 52, No. 46, 11.11.2013, p. 12077-12080.

Research output: Contribution to journalArticle

Boekhoven, Job ; Rubertpérez, Charles M. ; Sur, Shantanu ; Worthy, Amanda ; Stupp, Samuel I. / Dynamic display of bioactivity through host-guest chemistry. In: Angewandte Chemie - International Edition. 2013 ; Vol. 52, No. 46. pp. 12077-12080.
@article{6196b0d8302c43eea4a37d6466e1d0c2,
title = "Dynamic display of bioactivity through host-guest chemistry",
abstract = "A molecular host, β-cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS-containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non-spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non-bioactive sequence RGES.",
keywords = "biological signaling, cell adhesion, dynamics, host-guest chemistry, supramolecular chemistry",
author = "Job Boekhoven and Rubertp{\'e}rez, {Charles M.} and Shantanu Sur and Amanda Worthy and Stupp, {Samuel I}",
year = "2013",
month = "11",
day = "11",
doi = "10.1002/anie.201306278",
language = "English",
volume = "52",
pages = "12077--12080",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "46",

}

TY - JOUR

T1 - Dynamic display of bioactivity through host-guest chemistry

AU - Boekhoven, Job

AU - Rubertpérez, Charles M.

AU - Sur, Shantanu

AU - Worthy, Amanda

AU - Stupp, Samuel I

PY - 2013/11/11

Y1 - 2013/11/11

N2 - A molecular host, β-cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS-containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non-spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non-bioactive sequence RGES.

AB - A molecular host, β-cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS-containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non-spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non-bioactive sequence RGES.

KW - biological signaling

KW - cell adhesion

KW - dynamics

KW - host-guest chemistry

KW - supramolecular chemistry

UR - http://www.scopus.com/inward/record.url?scp=84887484952&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887484952&partnerID=8YFLogxK

U2 - 10.1002/anie.201306278

DO - 10.1002/anie.201306278

M3 - Article

C2 - 24108659

AN - SCOPUS:84887484952

VL - 52

SP - 12077

EP - 12080

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 46

ER -