Dynamic display of bioactivity through host-guest chemistry

Job Boekhoven, Charles M. Rubertpérez, Shantanu Sur, Amanda Worthy, Samuel I. Stupp

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

A molecular host, β-cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS-containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non-spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non-bioactive sequence RGES.

Original languageEnglish
Pages (from-to)12077-12080
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number46
DOIs
Publication statusPublished - Nov 11 2013

Keywords

  • biological signaling
  • cell adhesion
  • dynamics
  • host-guest chemistry
  • supramolecular chemistry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Dynamic display of bioactivity through host-guest chemistry'. Together they form a unique fingerprint.

  • Cite this