Abstract
A molecular host, β-cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS-containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non-spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non-bioactive sequence RGES.
| Original language | English |
|---|---|
| Pages (from-to) | 12077-12080 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 52 |
| Issue number | 46 |
| DOIs | |
| Publication status | Published - Nov 11 2013 |
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Keywords
- biological signaling
- cell adhesion
- dynamics
- host-guest chemistry
- supramolecular chemistry
ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
- Medicine(all)
Cite this
Dynamic display of bioactivity through host-guest chemistry. / Boekhoven, Job; Rubertpérez, Charles M.; Sur, Shantanu; Worthy, Amanda; Stupp, Samuel I.
In: Angewandte Chemie - International Edition, Vol. 52, No. 46, 11.11.2013, p. 12077-12080.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dynamic display of bioactivity through host-guest chemistry
AU - Boekhoven, Job
AU - Rubertpérez, Charles M.
AU - Sur, Shantanu
AU - Worthy, Amanda
AU - Stupp, Samuel I
PY - 2013/11/11
Y1 - 2013/11/11
N2 - A molecular host, β-cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS-containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non-spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non-bioactive sequence RGES.
AB - A molecular host, β-cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS-containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non-spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non-bioactive sequence RGES.
KW - biological signaling
KW - cell adhesion
KW - dynamics
KW - host-guest chemistry
KW - supramolecular chemistry
UR - http://www.scopus.com/inward/record.url?scp=84887484952&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887484952&partnerID=8YFLogxK
U2 - 10.1002/anie.201306278
DO - 10.1002/anie.201306278
M3 - Article
C2 - 24108659
AN - SCOPUS:84887484952
VL - 52
SP - 12077
EP - 12080
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 46
ER -