Abstract
A molecular host, β-cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS-containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non-spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non-bioactive sequence RGES.
| Original language | English |
|---|---|
| Pages (from-to) | 12077-12080 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 52 |
| Issue number | 46 |
| DOIs | |
| Publication status | Published - Nov 11 2013 |
Keywords
- biological signaling
- cell adhesion
- dynamics
- host-guest chemistry
- supramolecular chemistry
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
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Cite this
Boekhoven, J., Rubertpérez, C. M., Sur, S., Worthy, A., & Stupp, S. I. (2013). Dynamic display of bioactivity through host-guest chemistry. Angewandte Chemie - International Edition, 52(46), 12077-12080. https://doi.org/10.1002/anie.201306278