TY - JOUR
T1 - Dynamic display of bioactivity through host-guest chemistry
AU - Boekhoven, Job
AU - Rubertpérez, Charles M.
AU - Sur, Shantanu
AU - Worthy, Amanda
AU - Stupp, Samuel I.
PY - 2013/11/11
Y1 - 2013/11/11
N2 - A molecular host, β-cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS-containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non-spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non-bioactive sequence RGES.
AB - A molecular host, β-cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS-containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non-spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non-bioactive sequence RGES.
KW - biological signaling
KW - cell adhesion
KW - dynamics
KW - host-guest chemistry
KW - supramolecular chemistry
UR - http://www.scopus.com/inward/record.url?scp=84887484952&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887484952&partnerID=8YFLogxK
U2 - 10.1002/anie.201306278
DO - 10.1002/anie.201306278
M3 - Article
C2 - 24108659
AN - SCOPUS:84887484952
VL - 52
SP - 12077
EP - 12080
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 46
ER -