Dynamic display of bioactivity through host-guest chemistry

Job Boekhoven; Charles M. Rubertpérez; Shantanu Sur; Amanda Worthy; Samuel I. Stupp

doi:10.1002/anie.201306278

Dynamic display of bioactivity through host-guest chemistry

Job Boekhoven, Charles M. Rubertpérez, Shantanu Sur, Amanda Worthy, Samuel I. Stupp

Northwestern University

Research output: Contribution to journal › Article

75 Citations (Scopus)

Abstract

A molecular host, β-cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS-containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non-spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non-bioactive sequence RGES.

Original language	English
Pages (from-to)	12077-12080
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	46
DOIs	https://doi.org/10.1002/anie.201306278
Publication status	Published - Nov 11 2013

Fingerprint

Keywords

biological signaling
cell adhesion
dynamics
host-guest chemistry
supramolecular chemistry

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Cite this

Boekhoven, J., Rubertpérez, C. M., Sur, S., Worthy, A., & Stupp, S. I. (2013). Dynamic display of bioactivity through host-guest chemistry. Angewandte Chemie - International Edition, 52(46), 12077-12080. https://doi.org/10.1002/anie.201306278

@article{6196b0d8302c43eea4a37d6466e1d0c2,

title = "Dynamic display of bioactivity through host-guest chemistry",

abstract = "A molecular host, β-cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS-containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non-spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non-bioactive sequence RGES.",

keywords = "biological signaling, cell adhesion, dynamics, host-guest chemistry, supramolecular chemistry",

author = "Job Boekhoven and Rubertp{\'e}rez, {Charles M.} and Shantanu Sur and Amanda Worthy and Stupp, {Samuel I.}",

year = "2013",

month = nov

day = "11",

doi = "10.1002/anie.201306278",

language = "English",

volume = "52",

pages = "12077--12080",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "46",

}

TY - JOUR

T1 - Dynamic display of bioactivity through host-guest chemistry

AU - Boekhoven, Job

AU - Rubertpérez, Charles M.

AU - Sur, Shantanu

AU - Worthy, Amanda

AU - Stupp, Samuel I.

PY - 2013/11/11

Y1 - 2013/11/11

N2 - A molecular host, β-cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS-containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non-spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non-bioactive sequence RGES.

AB - A molecular host, β-cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS-containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non-spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non-bioactive sequence RGES.

KW - biological signaling

KW - cell adhesion

KW - dynamics

KW - host-guest chemistry

KW - supramolecular chemistry

UR - http://www.scopus.com/inward/record.url?scp=84887484952&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887484952&partnerID=8YFLogxK

U2 - 10.1002/anie.201306278

DO - 10.1002/anie.201306278

M3 - Article

C2 - 24108659

AN - SCOPUS:84887484952

VL - 52

SP - 12077

EP - 12080

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 46

ER -

Access to Document

10.1002/anie.201306278