Abstract
Steady-state and time-resolved fluorescence spectroscopies were used to investigate the local environments of coumarin 102 (C102) probe molecules when encapsulated within an amphiphilic starlike macromolecule (ASM). ASMs are promising surfactant-type nanoscale transporters of hydrophobic drug molecules. They consist of a hydrophobic core, in which small, hydrophobic molecules such as C102 can be encapsulated, and a hydrophilic shell that makes the whole assembly water-soluble. Steady-state fluorescence spectroscopy revealed that C102 molecules sense a very polar environment when encapsulated in ASMs. Both time-correlated single-photon counting and fluorescence upconversion techniques indicated that the solvent reorganization and diffusive reorientation of the C102 solvatochromic fluorescent probe are significantly slowed compared to the rates in aqueous solutions. These results provide insight into the dynamics of drugs encapsulated within ASMs.
| Original language | English |
|---|---|
| Pages (from-to) | 7463-7468 |
| Number of pages | 6 |
| Journal | Journal of Physical Chemistry B |
| Volume | 106 |
| Issue number | 30 |
| DOIs | |
| Publication status | Published - Aug 1 2002 |
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ASJC Scopus subject areas
- Physical and Theoretical Chemistry
Cite this
Dynamic fluorescence probing of the local environments within amphiphilic starlike macromolecules. / Frauchiger, Lotti; Shirota, Hideaki; Uhrich, Kathryn E.; Castner, Ed.
In: Journal of Physical Chemistry B, Vol. 106, No. 30, 01.08.2002, p. 7463-7468.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dynamic fluorescence probing of the local environments within amphiphilic starlike macromolecules
AU - Frauchiger, Lotti
AU - Shirota, Hideaki
AU - Uhrich, Kathryn E.
AU - Castner, Ed
PY - 2002/8/1
Y1 - 2002/8/1
N2 - Steady-state and time-resolved fluorescence spectroscopies were used to investigate the local environments of coumarin 102 (C102) probe molecules when encapsulated within an amphiphilic starlike macromolecule (ASM). ASMs are promising surfactant-type nanoscale transporters of hydrophobic drug molecules. They consist of a hydrophobic core, in which small, hydrophobic molecules such as C102 can be encapsulated, and a hydrophilic shell that makes the whole assembly water-soluble. Steady-state fluorescence spectroscopy revealed that C102 molecules sense a very polar environment when encapsulated in ASMs. Both time-correlated single-photon counting and fluorescence upconversion techniques indicated that the solvent reorganization and diffusive reorientation of the C102 solvatochromic fluorescent probe are significantly slowed compared to the rates in aqueous solutions. These results provide insight into the dynamics of drugs encapsulated within ASMs.
AB - Steady-state and time-resolved fluorescence spectroscopies were used to investigate the local environments of coumarin 102 (C102) probe molecules when encapsulated within an amphiphilic starlike macromolecule (ASM). ASMs are promising surfactant-type nanoscale transporters of hydrophobic drug molecules. They consist of a hydrophobic core, in which small, hydrophobic molecules such as C102 can be encapsulated, and a hydrophilic shell that makes the whole assembly water-soluble. Steady-state fluorescence spectroscopy revealed that C102 molecules sense a very polar environment when encapsulated in ASMs. Both time-correlated single-photon counting and fluorescence upconversion techniques indicated that the solvent reorganization and diffusive reorientation of the C102 solvatochromic fluorescent probe are significantly slowed compared to the rates in aqueous solutions. These results provide insight into the dynamics of drugs encapsulated within ASMs.
UR - http://www.scopus.com/inward/record.url?scp=0036703869&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036703869&partnerID=8YFLogxK
U2 - 10.1021/jp020746e
DO - 10.1021/jp020746e
M3 - Article
AN - SCOPUS:0036703869
VL - 106
SP - 7463
EP - 7468
JO - Journal of Physical Chemistry B Materials
JF - Journal of Physical Chemistry B Materials
SN - 1520-6106
IS - 30
ER -