Dynamic fluorescence probing of the local environments within amphiphilic starlike macromolecules

Lotti Frauchiger, Hideaki Shirota, Kathryn E. Uhrich, Ed Castner

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Steady-state and time-resolved fluorescence spectroscopies were used to investigate the local environments of coumarin 102 (C102) probe molecules when encapsulated within an amphiphilic starlike macromolecule (ASM). ASMs are promising surfactant-type nanoscale transporters of hydrophobic drug molecules. They consist of a hydrophobic core, in which small, hydrophobic molecules such as C102 can be encapsulated, and a hydrophilic shell that makes the whole assembly water-soluble. Steady-state fluorescence spectroscopy revealed that C102 molecules sense a very polar environment when encapsulated in ASMs. Both time-correlated single-photon counting and fluorescence upconversion techniques indicated that the solvent reorganization and diffusive reorientation of the C102 solvatochromic fluorescent probe are significantly slowed compared to the rates in aqueous solutions. These results provide insight into the dynamics of drugs encapsulated within ASMs.

Original languageEnglish
Pages (from-to)7463-7468
Number of pages6
JournalJournal of Physical Chemistry B
Volume106
Issue number30
DOIs
Publication statusPublished - Aug 1 2002

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Macromolecules
macromolecules
Fluorescence
fluorescence
Molecules
Fluorescence spectroscopy
molecules
drugs
transporter
probes
Fluorescent Dyes
Surface-Active Agents
Pharmaceutical Preparations
spectroscopy
retraining
counting
Surface active agents
Photons
assembly
surfactants

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

Cite this

Dynamic fluorescence probing of the local environments within amphiphilic starlike macromolecules. / Frauchiger, Lotti; Shirota, Hideaki; Uhrich, Kathryn E.; Castner, Ed.

In: Journal of Physical Chemistry B, Vol. 106, No. 30, 01.08.2002, p. 7463-7468.

Research output: Contribution to journalArticle

Frauchiger, Lotti ; Shirota, Hideaki ; Uhrich, Kathryn E. ; Castner, Ed. / Dynamic fluorescence probing of the local environments within amphiphilic starlike macromolecules. In: Journal of Physical Chemistry B. 2002 ; Vol. 106, No. 30. pp. 7463-7468.
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