Dynamics and energetics of hole trapping in DNA by 7-deazaguanine

Frederick D. Lewis; Jianqin Liu; Xiaoyang Liu; Xiaobing Zuo; Ryan T. Hayes; Michael R. Wasielewski

doi:10.1002/1521-3773(20020315)41:6<1026::AID-ANIE1026>3.0.CO;2-T

Dynamics and energetics of hole trapping in DNA by 7-deazaguanine

Frederick D. Lewis, Jianqin Liu, Xiaoyang Liu, Xiaobing Zuo, Ryan T. Hayes, Michael R. Wasielewski

Northwestern University

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

A deep hole trap is 7-deazaguanine (Z) - According to time-resolved transient absorption spectroscopy and kinetic modeling - For hole transport in DNA from a guanine (G) to a Z base across one or two intervening adenine-thymine base pairs. The Gibbs energy for hole transport from G to Z was determined to be - 0.19 eV, much larger than values for GG or GGG sites. Thus Z effectively prevents charge migration in DNA.

Original language	English
Pages (from-to)	1026-1028
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	41
Issue number	6
DOIs	https://doi.org/10.1002/1521-3773(20020315)41:6<1026::AID-ANIE1026>3.0.CO;2-T
Publication status	Published - Mar 15 2002

Keywords

DNA conjugates
Electron transfer
Photooxidation
Picosecond spectroscopy 1020-1022

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/1521-3773(20020315)41:6<1026::AID-ANIE1026>3.0.CO;2-T

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abstract = "A deep hole trap is 7-deazaguanine (Z) - According to time-resolved transient absorption spectroscopy and kinetic modeling - For hole transport in DNA from a guanine (G) to a Z base across one or two intervening adenine-thymine base pairs. The Gibbs energy for hole transport from G to Z was determined to be - 0.19 eV, much larger than values for GG or GGG sites. Thus Z effectively prevents charge migration in DNA.",

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AU - Hayes, Ryan T.

AU - Wasielewski, Michael R.

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