Dynamics and energetics of hole trapping in DNA by 7-deazaguanine

Frederick D. Lewis, Jianqin Liu, Xiaoyang Liu, Xiaobing Zuo, Ryan T. Hayes, Michael R Wasielewski

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A deep hole trap is 7-deazaguanine (Z) - According to time-resolved transient absorption spectroscopy and kinetic modeling - For hole transport in DNA from a guanine (G) to a Z base across one or two intervening adenine-thymine base pairs. The Gibbs energy for hole transport from G to Z was determined to be - 0.19 eV, much larger than values for GG or GGG sites. Thus Z effectively prevents charge migration in DNA.

Original languageEnglish
Pages (from-to)1026-1028
Number of pages3
JournalAngewandte Chemie - International Edition
Volume41
Issue number6
DOIs
Publication statusPublished - Mar 15 2002

Fingerprint

DNA
Hole traps
Thymine
Guanine
Adenine
Gibbs free energy
Absorption spectroscopy
Kinetics
7-deazaguanine

Keywords

  • DNA conjugates
  • Electron transfer
  • Photooxidation
  • Picosecond spectroscopy 1020-1022

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Dynamics and energetics of hole trapping in DNA by 7-deazaguanine. / Lewis, Frederick D.; Liu, Jianqin; Liu, Xiaoyang; Zuo, Xiaobing; Hayes, Ryan T.; Wasielewski, Michael R.

In: Angewandte Chemie - International Edition, Vol. 41, No. 6, 15.03.2002, p. 1026-1028.

Research output: Contribution to journalArticle

Lewis, Frederick D. ; Liu, Jianqin ; Liu, Xiaoyang ; Zuo, Xiaobing ; Hayes, Ryan T. ; Wasielewski, Michael R. / Dynamics and energetics of hole trapping in DNA by 7-deazaguanine. In: Angewandte Chemie - International Edition. 2002 ; Vol. 41, No. 6. pp. 1026-1028.
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