Dynamics and energetics of hole trapping in DNA by 7-deazaguanine

Frederick D. Lewis, Jianqin Liu, Xiaoyang Liu, Xiaobing Zuo, Ryan T. Hayes, Michael R. Wasielewski

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

A deep hole trap is 7-deazaguanine (Z) - According to time-resolved transient absorption spectroscopy and kinetic modeling - For hole transport in DNA from a guanine (G) to a Z base across one or two intervening adenine-thymine base pairs. The Gibbs energy for hole transport from G to Z was determined to be - 0.19 eV, much larger than values for GG or GGG sites. Thus Z effectively prevents charge migration in DNA.

Original languageEnglish
Pages (from-to)1026-1028
Number of pages3
JournalAngewandte Chemie - International Edition
Volume41
Issue number6
DOIs
Publication statusPublished - Mar 15 2002

Keywords

  • DNA conjugates
  • Electron transfer
  • Photooxidation
  • Picosecond spectroscopy 1020-1022

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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