Dynamics of Charge Injection and Charge Recombination in DNA Mini-Hairpins

Ashutosh Kumar Mishra, Michelle A. Harris, Ryan M. Young, Michael R Wasielewski, Frederick D. Lewis

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Steady state spectroscopy, femtosecond transient absorption spectroscopy (fsTA), and femtosecond stimulated Raman spectroscopy (FSRS) of DNA mini-hairpins possessing a diphenylacetylenedicarboxamide (DPA) linker and 1-3 adenine-thymine (A-T) or guanine-cytosine (G-C) base pairs have been investigated. Ultraviolet and circular dichroism (UV and CD) spectra are consistent with ground state conformations that are predominantly base-paired and π-stacked for conjugates possessing two or three base pairs; however, they offer no information concerning the conformation of conjugates possessing a single base pair. fsTA spectra are indicative of π-stacked structures excepted in the case of the conjugate possessing a single G-C base pair. All of the conjugates display transient absorption bands characteristic of the DPA-. anion radical. Conjugates possessing two or three G-C base pairs display a transient absorption band characteristic of the short-lived G+• cation radical. The mini-hairpins with 1-3 A-T base pairs do not display the transient absorption band characteristic of the (An +•) polaron. This implies that an A-tract with three base pairs is too short to support polaron formation.

Original languageEnglish
Pages (from-to)7042-7047
Number of pages6
JournalJournal of Physical Chemistry B
Volume121
Issue number29
DOIs
Publication statusPublished - Jul 27 2017

Fingerprint

Charge injection
DNA
deoxyribonucleic acid
injection
Cytosine
Guanine
Absorption spectra
Gene Conversion
guanines
Thymine
Adenine
Absorption spectroscopy
Conformations
thymine
adenines
absorption spectra
absorption spectroscopy
Dichroism
Ground state
Anions

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

Cite this

Dynamics of Charge Injection and Charge Recombination in DNA Mini-Hairpins. / Mishra, Ashutosh Kumar; Harris, Michelle A.; Young, Ryan M.; Wasielewski, Michael R; Lewis, Frederick D.

In: Journal of Physical Chemistry B, Vol. 121, No. 29, 27.07.2017, p. 7042-7047.

Research output: Contribution to journalArticle

Mishra, Ashutosh Kumar ; Harris, Michelle A. ; Young, Ryan M. ; Wasielewski, Michael R ; Lewis, Frederick D. / Dynamics of Charge Injection and Charge Recombination in DNA Mini-Hairpins. In: Journal of Physical Chemistry B. 2017 ; Vol. 121, No. 29. pp. 7042-7047.
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