Effect of Mg2+ cations on the dynamics and efficiency of hole transport in DNA

Arun Kalliat Thazhathveetil, Anton Trifonov, Michael R Wasielewski, Frederick D. Lewis

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effect of Mg2+ cations on the electronic spectra and dynamics and efficiency of hole transport has been determined by means of femtosecond time-resolved transient absorption spectroscopy for DNA hairpins possessing stilbene electron acceptor and donor chromophores. The results are compared with those obtained previously for the same hairpins in the presence of Na+ cations and for one hairpin with no added salt. Quantum yields and rate constants for charge separation are smaller in the presence of Mg2+ than Na+, the largest differences being observed for the hairpins with the largest number of base pairs. Slower charge separation is attributed to minor groove binding by Mg2+, which results in a stiffer duplex structure rather than a change in ground state geometry. Reduction in the Na+ concentration has little effect on either the dynamics or efficiency of hole transport.

Original languageEnglish
Pages (from-to)10359-10363
Number of pages5
JournalJournal of Physical Chemistry A
Volume118
Issue number45
DOIs
Publication statusPublished - Nov 13 2014

Fingerprint

polarization (charge separation)
Cations
deoxyribonucleic acid
cations
Stilbenes
stilbene
DNA
Quantum yield
Chromophores
Absorption spectroscopy
Base Pairing
electronic spectra
grooves
Ground state
chromophores
Rate constants
Spectrum Analysis
absorption spectroscopy
Salts
Electrons

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Medicine(all)

Cite this

Effect of Mg2+ cations on the dynamics and efficiency of hole transport in DNA. / Thazhathveetil, Arun Kalliat; Trifonov, Anton; Wasielewski, Michael R; Lewis, Frederick D.

In: Journal of Physical Chemistry A, Vol. 118, No. 45, 13.11.2014, p. 10359-10363.

Research output: Contribution to journalArticle

Thazhathveetil, Arun Kalliat ; Trifonov, Anton ; Wasielewski, Michael R ; Lewis, Frederick D. / Effect of Mg2+ cations on the dynamics and efficiency of hole transport in DNA. In: Journal of Physical Chemistry A. 2014 ; Vol. 118, No. 45. pp. 10359-10363.
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