Effective, selective hydroalkoxylation/cyclization of alkynyl and allenyl alcohols mediated by lanthanide catalysts

Xianghua Yu, Sung Yong Seo, Tobin J. Marks

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131 Citations (Scopus)


Catalytic hydroalkoxylation/cyclization reactions of alkynyl and allenyl alcohols are efficiently mediated by homoleptic lanthanide amides Ln[N(SiMe3)2]3 (Ln = La, Nd, Sm, Y, and Lu). Conversions are found to be highly selective with products distinctly different from those produced by conventional transition metal catalysts. Turnover frequencies as high as 18.0 h-1 at 60 °C are observed. Kinetic studies indicate that these transformations are zero-order in [substrate] and first-order in [catalyst]. Catalytic cycles are proposed in which insertion of C-C unsaturation into a Ln-O bond is turnover-limiting.

Original languageEnglish
Pages (from-to)7244-7245
Number of pages2
JournalJournal of the American Chemical Society
Issue number23
Publication statusPublished - Jun 13 2007


ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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