Efficient charge transport via DNA G-quadruplexes

Arun K. Thazhathveetil, Michelle A. Harris, Ryan M. Young, Michael R Wasielewski, Frederick D. Lewis

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The dynamics and efficiency of photoinduced charge transport has been investigated in DNA capped hairpins possessing a stilbenedicarboxamide (Sa) hole donor and stilbenediether (Sd) hole acceptor separated by DNA G-quadruplex structures possessing 2-to-4 tetrads by means of femtosecond and nanosecond transient absorption spectroscopy with global analysis. The results for the quadruplex structures are compared with those for the corresponding duplex structures having G-C base pairs in place of the G-tetrads. Following photoinduced charge separation to form a contact radical ion pair, hole transport to form the Sa-•/Sd+• chargeseparated state is slower but more efficient for the quadruplex vs duplex structures. Thus, the G-quadruplex serves as an effective conduit for positive charge rather than as a hole trap when inserted into a duplex, as previously postulated.

Original languageEnglish
Pages (from-to)1730-1733
Number of pages4
JournalJournal of the American Chemical Society
Volume139
Issue number5
DOIs
Publication statusPublished - Feb 8 2017

Fingerprint

G-Quadruplexes
Charge transfer
DNA
Hole traps
Absorption spectroscopy
Base Pairing
Spectrum Analysis
Ions

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Thazhathveetil, A. K., Harris, M. A., Young, R. M., Wasielewski, M. R., & Lewis, F. D. (2017). Efficient charge transport via DNA G-quadruplexes. Journal of the American Chemical Society, 139(5), 1730-1733. https://doi.org/10.1021/jacs.6b10265

Efficient charge transport via DNA G-quadruplexes. / Thazhathveetil, Arun K.; Harris, Michelle A.; Young, Ryan M.; Wasielewski, Michael R; Lewis, Frederick D.

In: Journal of the American Chemical Society, Vol. 139, No. 5, 08.02.2017, p. 1730-1733.

Research output: Contribution to journalArticle

Thazhathveetil, AK, Harris, MA, Young, RM, Wasielewski, MR & Lewis, FD 2017, 'Efficient charge transport via DNA G-quadruplexes', Journal of the American Chemical Society, vol. 139, no. 5, pp. 1730-1733. https://doi.org/10.1021/jacs.6b10265
Thazhathveetil, Arun K. ; Harris, Michelle A. ; Young, Ryan M. ; Wasielewski, Michael R ; Lewis, Frederick D. / Efficient charge transport via DNA G-quadruplexes. In: Journal of the American Chemical Society. 2017 ; Vol. 139, No. 5. pp. 1730-1733.
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