Efficient charge transport via DNA G-quadruplexes

Arun K. Thazhathveetil, Michelle A. Harris, Ryan M. Young, Michael R Wasielewski, Frederick D. Lewis

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The dynamics and efficiency of photoinduced charge transport has been investigated in DNA capped hairpins possessing a stilbenedicarboxamide (Sa) hole donor and stilbenediether (Sd) hole acceptor separated by DNA G-quadruplex structures possessing 2-to-4 tetrads by means of femtosecond and nanosecond transient absorption spectroscopy with global analysis. The results for the quadruplex structures are compared with those for the corresponding duplex structures having G-C base pairs in place of the G-tetrads. Following photoinduced charge separation to form a contact radical ion pair, hole transport to form the Sa-•/Sd+• chargeseparated state is slower but more efficient for the quadruplex vs duplex structures. Thus, the G-quadruplex serves as an effective conduit for positive charge rather than as a hole trap when inserted into a duplex, as previously postulated.

Original languageEnglish
Pages (from-to)1730-1733
Number of pages4
JournalJournal of the American Chemical Society
Volume139
Issue number5
DOIs
Publication statusPublished - Feb 8 2017

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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