Efficient homogeneous catalytic hydrogenation of esters to alcohols

Jing Zhang; Gregory Leitus; Yehoshoa Ben-David; David Milstein

doi:10.1002/anie.200503771

Efficient homogeneous catalytic hydrogenation of esters to alcohols

Jing Zhang, Gregory Leitus, Yehoshoa Ben-David, David Milstein

Weizmann Institute of Science, Israel

Research output: Contribution to journal › Article › peer-review

412 Citations (Scopus)

Abstract

(Chemical Equation Presented) With open arms: A ruthenium PNN complex (see scheme) catalyzes the hydrogenation of esters in high yields under neutral conditions. The analogous PNP complex is less active. A mechanism is proposed based on the hemilabile nature of the PNN ligand which allows a vacant site to be created by decoordination of the -CH₂NEt₂ arm.

Original language	English
Pages (from-to)	1113-1115
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	7
DOIs	https://doi.org/10.1002/anie.200503771
Publication status	Published - Feb 6 2006

Keywords

Alcohols
Esters
Homogeneous catalysis
Hydrogenation
Ruthenium

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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AU - Leitus, Gregory

AU - Ben-David, Yehoshoa

AU - Milstein, David

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KW - Alcohols

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KW - Homogeneous catalysis

KW - Hydrogenation

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