Efficient intramolecular hydroalkoxylation/cyclization of unactivated alkenols mediated by lanthanide triflate ionic liquids

Alma Dzudza, Tobin J. Marks

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Abstract

Lanthanide triflates, Ln(OTf) 3, serve as efficient catalysts for the intramolecular hydroalkoxylation (HO)/cyclization of primary/secondary and aliphatic/aromatic hydroxyalkenes in room temperature ionic liquids (RTlLs). Cyclizations are effective in the formation of five-and sixmembered oxygen heterocycles with Markovnikov-type selectivity. Reaction rates exhibit first-order dependence on [Ln 3+] and [substrate].

Original languageEnglish
Pages (from-to)1523-1526
Number of pages4
JournalOrganic Letters
Volume11
Issue number7
DOIs
Publication statusPublished - Apr 2 2009

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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