Electron bifurcation

John W. Peters, Anne Frances Miller, Anne K. Jones, Paul W. King, Michael W.W. Adams

Research output: Contribution to journalReview article

48 Citations (Scopus)

Abstract

Electron bifurcation is the recently recognized third mechanism of biological energy conservation. It simultaneously couples exergonic and endergonic oxidation-reduction reactions to circumvent thermodynamic barriers and minimize free energy loss. Little is known about the details of how electron bifurcating enzymes function, but specifics are beginning to emerge for several bifurcating enzymes. To date, those characterized contain a collection of redox cofactors including flavins and iron-sulfur clusters. Here we discuss the current understanding of bifurcating enzymes and the mechanistic features required to reversibly partition multiple electrons from a single redox site into exergonic and endergonic electron transfer paths.

Original languageEnglish
Pages (from-to)146-152
Number of pages7
JournalCurrent Opinion in Chemical Biology
Volume31
DOIs
Publication statusPublished - Apr 1 2016

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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    Peters, J. W., Miller, A. F., Jones, A. K., King, P. W., & Adams, M. W. W. (2016). Electron bifurcation. Current Opinion in Chemical Biology, 31, 146-152. https://doi.org/10.1016/j.cbpa.2016.03.007