Electronic interactions in helical stacked arrays of the modified DNA base pyrrolocytosine

Prakash P. Neelakandan, Martin McCullagh, George C Schatz, Frederick D. Lewis

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The thermal stability and ultraviolet and circular dichroism spectra of nine synthetic DNA hairpins possessing one or more PC-G base pairs (PC = pyrrolocytosine) have been investigated. One group of hairpins possess 1-5 sequential PC-G base pairs while another group possess two PC-G base pairs separated by 1-3 A-T base pairs. The first group displays a nearly linear dependence of UV and exciton-coupled circular dichroism (EC-CD) band intensity upon the number of neighboring chromophores, whereas the second group shows weak EC-CD only at the shortest distances between non-neighboring chromophores. This result stands in marked contrast to the exciton coupling seen between stilbene chromophores separated by as many as a dozen base pairs. The weak exciton coupling between non-neighboring PC chromophores, like that of the natural nucelobases, is attributed to their relatively weak electronic transition dipoles.

Original languageEnglish
Pages (from-to)5199-5204
Number of pages6
JournalJournal of Physical Chemistry B
Volume116
Issue number17
DOIs
Publication statusPublished - May 3 2012

Fingerprint

Chromophores
Excitons
Dichroism
DNA
deoxyribonucleic acid
chromophores
excitons
dichroism
electronics
interactions
Stilbenes
stilbene
Thermodynamic stability
thermal stability
LDS 751
dipoles

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Materials Chemistry
  • Surfaces, Coatings and Films

Cite this

Electronic interactions in helical stacked arrays of the modified DNA base pyrrolocytosine. / Neelakandan, Prakash P.; McCullagh, Martin; Schatz, George C; Lewis, Frederick D.

In: Journal of Physical Chemistry B, Vol. 116, No. 17, 03.05.2012, p. 5199-5204.

Research output: Contribution to journalArticle

Neelakandan, Prakash P. ; McCullagh, Martin ; Schatz, George C ; Lewis, Frederick D. / Electronic interactions in helical stacked arrays of the modified DNA base pyrrolocytosine. In: Journal of Physical Chemistry B. 2012 ; Vol. 116, No. 17. pp. 5199-5204.
@article{9bede513c199411d8a76b945613add51,
title = "Electronic interactions in helical stacked arrays of the modified DNA base pyrrolocytosine",
abstract = "The thermal stability and ultraviolet and circular dichroism spectra of nine synthetic DNA hairpins possessing one or more PC-G base pairs (PC = pyrrolocytosine) have been investigated. One group of hairpins possess 1-5 sequential PC-G base pairs while another group possess two PC-G base pairs separated by 1-3 A-T base pairs. The first group displays a nearly linear dependence of UV and exciton-coupled circular dichroism (EC-CD) band intensity upon the number of neighboring chromophores, whereas the second group shows weak EC-CD only at the shortest distances between non-neighboring chromophores. This result stands in marked contrast to the exciton coupling seen between stilbene chromophores separated by as many as a dozen base pairs. The weak exciton coupling between non-neighboring PC chromophores, like that of the natural nucelobases, is attributed to their relatively weak electronic transition dipoles.",
author = "Neelakandan, {Prakash P.} and Martin McCullagh and Schatz, {George C} and Lewis, {Frederick D.}",
year = "2012",
month = "5",
day = "3",
doi = "10.1021/jp302385c",
language = "English",
volume = "116",
pages = "5199--5204",
journal = "Journal of Physical Chemistry B Materials",
issn = "1520-6106",
publisher = "American Chemical Society",
number = "17",

}

TY - JOUR

T1 - Electronic interactions in helical stacked arrays of the modified DNA base pyrrolocytosine

AU - Neelakandan, Prakash P.

AU - McCullagh, Martin

AU - Schatz, George C

AU - Lewis, Frederick D.

PY - 2012/5/3

Y1 - 2012/5/3

N2 - The thermal stability and ultraviolet and circular dichroism spectra of nine synthetic DNA hairpins possessing one or more PC-G base pairs (PC = pyrrolocytosine) have been investigated. One group of hairpins possess 1-5 sequential PC-G base pairs while another group possess two PC-G base pairs separated by 1-3 A-T base pairs. The first group displays a nearly linear dependence of UV and exciton-coupled circular dichroism (EC-CD) band intensity upon the number of neighboring chromophores, whereas the second group shows weak EC-CD only at the shortest distances between non-neighboring chromophores. This result stands in marked contrast to the exciton coupling seen between stilbene chromophores separated by as many as a dozen base pairs. The weak exciton coupling between non-neighboring PC chromophores, like that of the natural nucelobases, is attributed to their relatively weak electronic transition dipoles.

AB - The thermal stability and ultraviolet and circular dichroism spectra of nine synthetic DNA hairpins possessing one or more PC-G base pairs (PC = pyrrolocytosine) have been investigated. One group of hairpins possess 1-5 sequential PC-G base pairs while another group possess two PC-G base pairs separated by 1-3 A-T base pairs. The first group displays a nearly linear dependence of UV and exciton-coupled circular dichroism (EC-CD) band intensity upon the number of neighboring chromophores, whereas the second group shows weak EC-CD only at the shortest distances between non-neighboring chromophores. This result stands in marked contrast to the exciton coupling seen between stilbene chromophores separated by as many as a dozen base pairs. The weak exciton coupling between non-neighboring PC chromophores, like that of the natural nucelobases, is attributed to their relatively weak electronic transition dipoles.

UR - http://www.scopus.com/inward/record.url?scp=84860523929&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860523929&partnerID=8YFLogxK

U2 - 10.1021/jp302385c

DO - 10.1021/jp302385c

M3 - Article

C2 - 22486518

AN - SCOPUS:84860523929

VL - 116

SP - 5199

EP - 5204

JO - Journal of Physical Chemistry B Materials

JF - Journal of Physical Chemistry B Materials

SN - 1520-6106

IS - 17

ER -