Electrostatic control of bioactivity

Joshua E. Goldberger, Eric J. Berns, Ronit Bitton, Christina J. Newcomb, Samuel I Stupp

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The power of independence: When exhibited on the surface of self-assembling peptide-amphiphile nanofibers, the hydrophobic laminin-derived IKVAV epitope induced nanofiber bundling through interdigitation with neighboring fibers and thus decreased the bioactivity of the resulting materials. The inclusion of charged amino acids in the peptide amphiphiles disrupted the tendency to bundle and led to significantly enhanced neurite outgrowth (see picture).

Original languageEnglish
Pages (from-to)6292-6295
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number28
DOIs
Publication statusPublished - Jul 4 2011

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Keywords

  • aggregation
  • biological activity
  • nanostructures
  • peptides
  • self-assembly

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Goldberger, J. E., Berns, E. J., Bitton, R., Newcomb, C. J., & Stupp, S. I. (2011). Electrostatic control of bioactivity. Angewandte Chemie - International Edition, 50(28), 6292-6295. https://doi.org/10.1002/anie.201100202