Electrostatic control of bioactivity

Joshua E. Goldberger, Eric J. Berns, Ronit Bitton, Christina J. Newcomb, Samuel I. Stupp

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)


The power of independence: When exhibited on the surface of self-assembling peptide-amphiphile nanofibers, the hydrophobic laminin-derived IKVAV epitope induced nanofiber bundling through interdigitation with neighboring fibers and thus decreased the bioactivity of the resulting materials. The inclusion of charged amino acids in the peptide amphiphiles disrupted the tendency to bundle and led to significantly enhanced neurite outgrowth (see picture).

Original languageEnglish
Pages (from-to)6292-6295
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number28
Publication statusPublished - Jul 4 2011


  • aggregation
  • biological activity
  • nanostructures
  • peptides
  • self-assembly

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Electrostatic control of bioactivity'. Together they form a unique fingerprint.

Cite this