Electrostatic control of structure in self-assembled membranes

Ronit Bitton, Lesley W. Chow, R. Helen Zha, Yuri S. Velichko, E. Thomas Pashuck, Samuel I Stupp

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Self-assembling peptide amphiphiles (PAs) can form hierarchically ordered membranes when brought in contact with aqueous polyelectrolytes of the opposite charge by rapidly creating a diffusion barrier composed of filamentous nanostructures parallel to the plane of the incipient membrane. Following this event, osmotic forces and charge complexation template nanofiber growth perpendicular to the plane of the membrane in a dynamic self-assembly process. In this work, we show that this hierarchical structure requires massive interfacial aggregation of PA molecules, suggesting the importance of rapid diffusion barrier formation. Strong PA aggregation is induced here through the use of heparin-binding PAs with heparin and also with polyelectrolytes of varying charge density. Small angle X-ray scattering shows that in the case of weak PA-polyelectrolyte interaction, membranes formed display a cubic phase ordering on the nanoscale that likely results from clusters of PA nanostructures surrounded by polyelectrolyte chains.

Original languageEnglish
Pages (from-to)500-505
Number of pages6
JournalSmall
Volume10
Issue number3
DOIs
Publication statusPublished - Feb 12 2014

Fingerprint

Amphiphiles
Static Electricity
Peptides
Electrostatics
Polyelectrolytes
Membranes
Diffusion barriers
Nanostructures
Heparin
Agglomeration
Nanofibers
Charge density
Complexation
X ray scattering
Self assembly
X-Rays
Molecules
Growth

Keywords

  • ordered membranes
  • peptide amphiphiles
  • polyelectrolyte-supramolecular polymer complex
  • SAXS
  • self-assembly

ASJC Scopus subject areas

  • Biomaterials
  • Engineering (miscellaneous)
  • Biotechnology
  • Medicine(all)

Cite this

Bitton, R., Chow, L. W., Zha, R. H., Velichko, Y. S., Pashuck, E. T., & Stupp, S. I. (2014). Electrostatic control of structure in self-assembled membranes. Small, 10(3), 500-505. https://doi.org/10.1002/smll.201300254

Electrostatic control of structure in self-assembled membranes. / Bitton, Ronit; Chow, Lesley W.; Zha, R. Helen; Velichko, Yuri S.; Pashuck, E. Thomas; Stupp, Samuel I.

In: Small, Vol. 10, No. 3, 12.02.2014, p. 500-505.

Research output: Contribution to journalArticle

Bitton, R, Chow, LW, Zha, RH, Velichko, YS, Pashuck, ET & Stupp, SI 2014, 'Electrostatic control of structure in self-assembled membranes', Small, vol. 10, no. 3, pp. 500-505. https://doi.org/10.1002/smll.201300254
Bitton R, Chow LW, Zha RH, Velichko YS, Pashuck ET, Stupp SI. Electrostatic control of structure in self-assembled membranes. Small. 2014 Feb 12;10(3):500-505. https://doi.org/10.1002/smll.201300254
Bitton, Ronit ; Chow, Lesley W. ; Zha, R. Helen ; Velichko, Yuri S. ; Pashuck, E. Thomas ; Stupp, Samuel I. / Electrostatic control of structure in self-assembled membranes. In: Small. 2014 ; Vol. 10, No. 3. pp. 500-505.
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