Encapsulation of a Nerve Agent Detoxifying Enzyme by a Mesoporous Zirconium Metal-Organic Framework Engenders Thermal and Long-Term Stability

Peng Li, Su Young Moon, Mark A. Guelta, Steven P. Harvey, Joseph T Hupp, Omar K. Farha

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Immobilized enzymes typically have greater thermal and operational stability than their soluble form. Here we report that for the first time, a nerve agent detoxifying enzyme, organophosphorus acid anhydrolase (OPAA), has been successfully encapsulated into a water-stable zirconium metal-organic framework (MOF). This MOF features a hierarchical mesoporous channel structure and exhibits a 12 wt % loading capacity of OPAA. The thermal and long-term stabilities of OPAA are both significantly enhanced after immobilization.

Original languageEnglish
Pages (from-to)8052-8055
Number of pages4
JournalJournal of the American Chemical Society
Volume138
Issue number26
DOIs
Publication statusPublished - Jul 6 2016

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Aryldialkylphosphatase
Encapsulation
Zirconium
Enzymes
Hot Temperature
Metals
Acids
Immobilized Enzymes
Immobilization
Water
Nerve Agents

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Encapsulation of a Nerve Agent Detoxifying Enzyme by a Mesoporous Zirconium Metal-Organic Framework Engenders Thermal and Long-Term Stability. / Li, Peng; Moon, Su Young; Guelta, Mark A.; Harvey, Steven P.; Hupp, Joseph T; Farha, Omar K.

In: Journal of the American Chemical Society, Vol. 138, No. 26, 06.07.2016, p. 8052-8055.

Research output: Contribution to journalArticle

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