Encapsulation of a Nerve Agent Detoxifying Enzyme by a Mesoporous Zirconium Metal-Organic Framework Engenders Thermal and Long-Term Stability

Peng Li, Su Young Moon, Mark A. Guelta, Steven P. Harvey, Joseph T Hupp, Omar K. Farha

Research output: Contribution to journalArticle

130 Citations (Scopus)


Immobilized enzymes typically have greater thermal and operational stability than their soluble form. Here we report that for the first time, a nerve agent detoxifying enzyme, organophosphorus acid anhydrolase (OPAA), has been successfully encapsulated into a water-stable zirconium metal-organic framework (MOF). This MOF features a hierarchical mesoporous channel structure and exhibits a 12 wt % loading capacity of OPAA. The thermal and long-term stabilities of OPAA are both significantly enhanced after immobilization.

Original languageEnglish
Pages (from-to)8052-8055
Number of pages4
JournalJournal of the American Chemical Society
Issue number26
Publication statusPublished - Jul 6 2016


ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

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