Encapsulation of pyrene within self-assembled peptide amphiphile nanofibers

Mustafa O. Guler, Randal C. Claussen, Samuel I Stupp

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Certain peptide amphiphiles (PAs) in aqueous media are known to form high-aspect-ratio cylindrical nanofibers with hydrophobic cores. Using cholesterol or palmitic acid as the hydrophobe and the biological adhesion epitope RGDS as the hydrophilic segment, we studied the encapsulation of pyrene, a small hydrophobic molecule, within the cores of the self-assembling PA nanofibers. Circular dichroism (CD), transmission electron microscopy (TEM) and fluorescence were used to characterize formation of the supramolecular structures. Pyrene excimer formation observed by fluorescence demonstrated the encapsulation and aggregation of pyrene within the hydrophobic cores. In addition, peptide amphiphiles covalently functionalized with pyrene linked to the hydrophobic portion of the molecule exhibited excimer formation upon self-assembly into nanofibers. Interestingly excimer formation was not observed in similar molecules that formed spherical aggregates rather than cylindrical nanofibers.

Original languageEnglish
Pages (from-to)4507-4512
Number of pages6
JournalJournal of Materials Chemistry
Volume15
Issue number42
DOIs
Publication statusPublished - Nov 14 2005

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Amphiphiles
Pyrene
pyrenes
Nanofibers
Encapsulation
Peptides
peptides
excimers
Molecules
Fluorescence
palmitic acid
Palmitic acid
Epitopes
molecules
fluorescence
Palmitic Acid
Cholesterol
cholesterol
Dichroism
assembling

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Materials Chemistry
  • Materials Science(all)

Cite this

Encapsulation of pyrene within self-assembled peptide amphiphile nanofibers. / Guler, Mustafa O.; Claussen, Randal C.; Stupp, Samuel I.

In: Journal of Materials Chemistry, Vol. 15, No. 42, 14.11.2005, p. 4507-4512.

Research output: Contribution to journalArticle

Guler, Mustafa O. ; Claussen, Randal C. ; Stupp, Samuel I. / Encapsulation of pyrene within self-assembled peptide amphiphile nanofibers. In: Journal of Materials Chemistry. 2005 ; Vol. 15, No. 42. pp. 4507-4512.
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