Energetics and mechanism of organolanthanide-mediated phosphinoalkene hydrophosphination/cyclization. A density functional theory analysis

Alessandro Motta, Ignazio L. Fragalà, Tobin J. Marks

Research output: Contribution to journalArticle

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Abstract

This contribution focuses on organolanthanide-mediated hydrophosphination processes and analyzes the hydrophosphination/cyclization of a prototypical phosphinoalkene, H2P(CH2)3-CH=CH2, catalyzed by Cp2LaCH(TMS)2, using density functional theory methods, and compares/contrasts the results to analogous hydroamination/cyclization processes. The reaction is found to proceed in two discrete steps: namely, cyclization via C=C insertion into the Cp 2La-P(phosphido) linkage to form La-C and C-P bonds and subsequent La-C protonolysis. Calculations have been carried out for: (i) insertion of the olefinic moiety into the La-P bond and (ii) La-C protonolysis by a second substrate molecule. The cyclized phosphinoalkane is released in the latter process and the active catalyst regenerated. DFT energetic profiles have been generated for the entire catalytic cycle. DFT-derived geometries and stabilities of reactants, intermediates, and products have also been analyzed. The picture that emerges is one of approximately thermoneutral insertion of the alkene fragment into the Cp2La-P(phosphido) bond via a highly organized, seven-membered chairlike cyclic transition state. The resulting cyclopentylmethyl complex then undergoes turnover-limiting but exothermic protonolysis to yield a phosphine-phosphide complex, the likely resting state of the catalyst. Interestingly, this energetic ordering of barriers is exactly reversed from that in the formally analogous hydroamination/cyclization process, where C=C insertion is turnover-limiting and protonolysis rapid. The calculations provide evidence that, in the hydrophosphination/cyclization process, there is competition at the lanthanide center between cyclized product and incoming unconverted substrate and, therefore, some inhibition of the protonolysis step, in accord with experiment. Parallel calculations demonstrate that such effects are not generally important in the analogous hydroamination/cyclization process. Derived thermodynamic and kinetic parameters are in excellent agreement with experiment.

Original languageEnglish
Pages (from-to)4995-5003
Number of pages9
JournalOrganometallics
Volume24
Issue number21
DOIs
Publication statusPublished - Oct 10 2005

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Cyclization
Density functional theory
insertion
density functional theory
phosphine
catalysts
Discrete Fourier transforms
phosphides
products
phosphines
linkages
alkenes
Lanthanoid Series Elements
Catalysts
fragments
Alkenes
Substrates
methylidyne
Kinetic parameters
thermodynamics

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry

Cite this

Energetics and mechanism of organolanthanide-mediated phosphinoalkene hydrophosphination/cyclization. A density functional theory analysis. / Motta, Alessandro; Fragalà, Ignazio L.; Marks, Tobin J.

In: Organometallics, Vol. 24, No. 21, 10.10.2005, p. 4995-5003.

Research output: Contribution to journalArticle

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