Energy landscapes and functions of supramolecular systems

Faifan Tantakitti, Job Boekhoven, Xin Wang, Roman V. Kazantsev, Tao Yu, Jiahe Li, Ellen Zhuang, Roya Zandi, Julia H. Ortony, Christina J. Newcomb, Liam C. Palmer, Gajendra S. Shekhawat, Monica Olvera de la Cruz, George C Schatz, Samuel I Stupp

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

By means of two supramolecular systems—peptide amphiphiles engaged in hydrogen-bonded β-sheets, and chromophore amphiphiles driven to assemble by π-orbital overlaps—we show that the minima in the energy landscapes of supramolecular systems are defined by electrostatic repulsion and the ability of the dominant attractive forces to trap molecules in thermodynamically unfavourable configurations. These competing interactions can be selectively switched on and off, with the order of doing so determining the position of the final product in the energy landscape. Within the same energy landscape, the peptide-amphiphile system forms a thermodynamically favoured product characterized by long bundled fibres that promote biological cell adhesion and survival, and a metastable product characterized by short monodisperse fibres that interfere with adhesion and can lead to cell death. Our findings suggest that, in supramolecular systems, functions and energy landscapes are linked, superseding the more traditional connection between molecular design and function.

Original languageEnglish
JournalNature Materials
DOIs
Publication statusAccepted/In press - Jan 18 2016

Fingerprint

Amphiphiles
adhesion
products
Fibers
Cell adhesion
Cell death
Chromophores
Peptides
fibers
energy
Hydrogen
Electrostatics
Adhesion
death
chromophores
peptides
Molecules
traps
electrostatics
orbitals

ASJC Scopus subject areas

  • Mechanical Engineering
  • Mechanics of Materials
  • Condensed Matter Physics
  • Materials Science(all)
  • Chemistry(all)

Cite this

Tantakitti, F., Boekhoven, J., Wang, X., Kazantsev, R. V., Yu, T., Li, J., ... Stupp, S. I. (Accepted/In press). Energy landscapes and functions of supramolecular systems. Nature Materials. https://doi.org/10.1038/nmat4538

Energy landscapes and functions of supramolecular systems. / Tantakitti, Faifan; Boekhoven, Job; Wang, Xin; Kazantsev, Roman V.; Yu, Tao; Li, Jiahe; Zhuang, Ellen; Zandi, Roya; Ortony, Julia H.; Newcomb, Christina J.; Palmer, Liam C.; Shekhawat, Gajendra S.; de la Cruz, Monica Olvera; Schatz, George C; Stupp, Samuel I.

In: Nature Materials, 18.01.2016.

Research output: Contribution to journalArticle

Tantakitti, F, Boekhoven, J, Wang, X, Kazantsev, RV, Yu, T, Li, J, Zhuang, E, Zandi, R, Ortony, JH, Newcomb, CJ, Palmer, LC, Shekhawat, GS, de la Cruz, MO, Schatz, GC & Stupp, SI 2016, 'Energy landscapes and functions of supramolecular systems', Nature Materials. https://doi.org/10.1038/nmat4538
Tantakitti F, Boekhoven J, Wang X, Kazantsev RV, Yu T, Li J et al. Energy landscapes and functions of supramolecular systems. Nature Materials. 2016 Jan 18. https://doi.org/10.1038/nmat4538
Tantakitti, Faifan ; Boekhoven, Job ; Wang, Xin ; Kazantsev, Roman V. ; Yu, Tao ; Li, Jiahe ; Zhuang, Ellen ; Zandi, Roya ; Ortony, Julia H. ; Newcomb, Christina J. ; Palmer, Liam C. ; Shekhawat, Gajendra S. ; de la Cruz, Monica Olvera ; Schatz, George C ; Stupp, Samuel I. / Energy landscapes and functions of supramolecular systems. In: Nature Materials. 2016.
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