Enhancing DNA-Mediated Assemblies of Supramolecular Cage Dimers through Tuning Core Flexibility and DNA Length-A Combined Experimental-Modeling Study

Bong Jin Hong, Vincent Y. Cho, Reiner Bleher, George C Schatz, SonBinh T. Nguyen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Two complementary small-molecule-DNA hybrid (SMDH) building blocks have been combined to form well-defined supramolecular cage dimers at DNA concentrations as high as 102 μM. This was made possible by combining a flexible small-molecule core and three DNA arms of moderate lengths (3) components: sharp, enhanced melting transitions were observed for assemblies that result mostly in cage dimers, while no cooperative melting behavior was observed for assemblies that form ill-defined networks.

Original languageEnglish
Pages (from-to)13381-13388
Number of pages8
JournalJournal of the American Chemical Society
Volume137
Issue number41
DOIs
Publication statusPublished - Oct 21 2015

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Dimers
DNA
Tuning
Freezing
Melting
Molecules
Cooperative Behavior

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Enhancing DNA-Mediated Assemblies of Supramolecular Cage Dimers through Tuning Core Flexibility and DNA Length-A Combined Experimental-Modeling Study. / Hong, Bong Jin; Cho, Vincent Y.; Bleher, Reiner; Schatz, George C; Nguyen, SonBinh T.

In: Journal of the American Chemical Society, Vol. 137, No. 41, 21.10.2015, p. 13381-13388.

Research output: Contribution to journalArticle

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