Abstract
Detailed experimental and computational studies revealed the important role that hydrophobic interactions play in the aqueous assembly of rigid small molecule-DNA hybrid (rSMDH) building blocks into nanoscale cage and face-to-face (ff) dimeric structures. In aqueous environments, the hydrophobic surfaces of the organic cores in these nanostructures are minimized by interactions with the core in another rSMDHs, with the bases in the attached DNA strands, and/or with the base pairs in the final assembled structures. In the case that the hydrophobic surfaces of the cores could not be properly isolated in the assembly process, an ill-defined network results instead of dimers, even at low concentration of DNA. In contrast, if ff dimers can be formed with good minimization of the exposed hydrophobic surfaces of the cores, they are highly stable structures with enhanced melting temperatures and cooperative melting behavior.
| Original language | English |
|---|---|
| Pages (from-to) | 7450-7458 |
| Number of pages | 9 |
| Journal | Journal of the American Chemical Society |
| Volume | 134 |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - May 2 2012 |
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ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
- Biochemistry
- Colloid and Surface Chemistry
Cite this
Enhancing the melting properties of small molecule-DNA hybrids through designed hydrophobic interactions : An experimental-computational study. / Eryazici, Ibrahim; Yildirim, Ilyas; Schatz, George C; Nguyen, Sonbinh T.
In: Journal of the American Chemical Society, Vol. 134, No. 17, 02.05.2012, p. 7450-7458.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enhancing the melting properties of small molecule-DNA hybrids through designed hydrophobic interactions
T2 - An experimental-computational study
AU - Eryazici, Ibrahim
AU - Yildirim, Ilyas
AU - Schatz, George C
AU - Nguyen, Sonbinh T.
PY - 2012/5/2
Y1 - 2012/5/2
N2 - Detailed experimental and computational studies revealed the important role that hydrophobic interactions play in the aqueous assembly of rigid small molecule-DNA hybrid (rSMDH) building blocks into nanoscale cage and face-to-face (ff) dimeric structures. In aqueous environments, the hydrophobic surfaces of the organic cores in these nanostructures are minimized by interactions with the core in another rSMDHs, with the bases in the attached DNA strands, and/or with the base pairs in the final assembled structures. In the case that the hydrophobic surfaces of the cores could not be properly isolated in the assembly process, an ill-defined network results instead of dimers, even at low concentration of DNA. In contrast, if ff dimers can be formed with good minimization of the exposed hydrophobic surfaces of the cores, they are highly stable structures with enhanced melting temperatures and cooperative melting behavior.
AB - Detailed experimental and computational studies revealed the important role that hydrophobic interactions play in the aqueous assembly of rigid small molecule-DNA hybrid (rSMDH) building blocks into nanoscale cage and face-to-face (ff) dimeric structures. In aqueous environments, the hydrophobic surfaces of the organic cores in these nanostructures are minimized by interactions with the core in another rSMDHs, with the bases in the attached DNA strands, and/or with the base pairs in the final assembled structures. In the case that the hydrophobic surfaces of the cores could not be properly isolated in the assembly process, an ill-defined network results instead of dimers, even at low concentration of DNA. In contrast, if ff dimers can be formed with good minimization of the exposed hydrophobic surfaces of the cores, they are highly stable structures with enhanced melting temperatures and cooperative melting behavior.
UR - http://www.scopus.com/inward/record.url?scp=84860801424&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860801424&partnerID=8YFLogxK
U2 - 10.1021/ja300322a
DO - 10.1021/ja300322a
M3 - Article
C2 - 22428783
AN - SCOPUS:84860801424
VL - 134
SP - 7450
EP - 7458
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 17
ER -