Enzyme directed templating of artificial bone mineral

Erik D. Spoerke, Shawn G. Anthony, Samuel I Stupp

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

A 3D gel matrix that templates biomimetic hydroxyapatite (HA) mineralization was studied. The artificial nanofiber matrix described is a 3D network of peptide amphiphile nanofibers. The study uses a PA, which was synthesized using an Applied Biosystems 433A automated peptide synthesizer using standard FOC chemistry and studied under Fourier-transform infrared (FTIR). The enzymatic mediated harvesting of phosphate ions combined with nanofiber surface nucleation, which can lead to a spatially selective and biomimetic mineralization in a 3D environment was shown. The study suggested that both spatial and temporal elements are necessary to achieve biomimetic mineralization in synthetic materials. The study also suggested the future work which mat offer strategies in the design of other advanced materials.

Original languageEnglish
Pages (from-to)425-430
Number of pages6
JournalAdvanced Materials
Volume21
Issue number4
DOIs
Publication statusPublished - Jan 26 2009

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Biomimetics
Nanofibers
Minerals
Bone
Enzymes
Peptides
Amphiphiles
Durapatite
Hydroxyapatite
Fourier transforms
Phosphates
Nucleation
Gels
Ions
Infrared radiation

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Enzyme directed templating of artificial bone mineral. / Spoerke, Erik D.; Anthony, Shawn G.; Stupp, Samuel I.

In: Advanced Materials, Vol. 21, No. 4, 26.01.2009, p. 425-430.

Research output: Contribution to journalArticle

Spoerke, Erik D. ; Anthony, Shawn G. ; Stupp, Samuel I. / Enzyme directed templating of artificial bone mineral. In: Advanced Materials. 2009 ; Vol. 21, No. 4. pp. 425-430.
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