Abstract
A 3D gel matrix that templates biomimetic hydroxyapatite (HA) mineralization was studied. The artificial nanofiber matrix described is a 3D network of peptide amphiphile nanofibers. The study uses a PA, which was synthesized using an Applied Biosystems 433A automated peptide synthesizer using standard FOC chemistry and studied under Fourier-transform infrared (FTIR). The enzymatic mediated harvesting of phosphate ions combined with nanofiber surface nucleation, which can lead to a spatially selective and biomimetic mineralization in a 3D environment was shown. The study suggested that both spatial and temporal elements are necessary to achieve biomimetic mineralization in synthetic materials. The study also suggested the future work which mat offer strategies in the design of other advanced materials.
| Original language | English |
|---|---|
| Pages (from-to) | 425-430 |
| Number of pages | 6 |
| Journal | Advanced Materials |
| Volume | 21 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jan 26 2009 |
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ASJC Scopus subject areas
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering
Cite this
Enzyme directed templating of artificial bone mineral. / Spoerke, Erik D.; Anthony, Shawn G.; Stupp, Samuel I.
In: Advanced Materials, Vol. 21, No. 4, 26.01.2009, p. 425-430.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enzyme directed templating of artificial bone mineral
AU - Spoerke, Erik D.
AU - Anthony, Shawn G.
AU - Stupp, Samuel I
PY - 2009/1/26
Y1 - 2009/1/26
N2 - A 3D gel matrix that templates biomimetic hydroxyapatite (HA) mineralization was studied. The artificial nanofiber matrix described is a 3D network of peptide amphiphile nanofibers. The study uses a PA, which was synthesized using an Applied Biosystems 433A automated peptide synthesizer using standard FOC chemistry and studied under Fourier-transform infrared (FTIR). The enzymatic mediated harvesting of phosphate ions combined with nanofiber surface nucleation, which can lead to a spatially selective and biomimetic mineralization in a 3D environment was shown. The study suggested that both spatial and temporal elements are necessary to achieve biomimetic mineralization in synthetic materials. The study also suggested the future work which mat offer strategies in the design of other advanced materials.
AB - A 3D gel matrix that templates biomimetic hydroxyapatite (HA) mineralization was studied. The artificial nanofiber matrix described is a 3D network of peptide amphiphile nanofibers. The study uses a PA, which was synthesized using an Applied Biosystems 433A automated peptide synthesizer using standard FOC chemistry and studied under Fourier-transform infrared (FTIR). The enzymatic mediated harvesting of phosphate ions combined with nanofiber surface nucleation, which can lead to a spatially selective and biomimetic mineralization in a 3D environment was shown. The study suggested that both spatial and temporal elements are necessary to achieve biomimetic mineralization in synthetic materials. The study also suggested the future work which mat offer strategies in the design of other advanced materials.
UR - http://www.scopus.com/inward/record.url?scp=59249083772&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=59249083772&partnerID=8YFLogxK
U2 - 10.1002/adma.200802242
DO - 10.1002/adma.200802242
M3 - Article
AN - SCOPUS:59249083772
VL - 21
SP - 425
EP - 430
JO - Advanced Materials
JF - Advanced Materials
SN - 0935-9648
IS - 4
ER -