Enzyme directed templating of artificial bone mineral

Erik D. Spoerke, Shawn G. Anthony, Samuel I. Stupp

Research output: Contribution to journalArticlepeer-review

148 Citations (Scopus)


A 3D gel matrix that templates biomimetic hydroxyapatite (HA) mineralization was studied. The artificial nanofiber matrix described is a 3D network of peptide amphiphile nanofibers. The study uses a PA, which was synthesized using an Applied Biosystems 433A automated peptide synthesizer using standard FOC chemistry and studied under Fourier-transform infrared (FTIR). The enzymatic mediated harvesting of phosphate ions combined with nanofiber surface nucleation, which can lead to a spatially selective and biomimetic mineralization in a 3D environment was shown. The study suggested that both spatial and temporal elements are necessary to achieve biomimetic mineralization in synthetic materials. The study also suggested the future work which mat offer strategies in the design of other advanced materials.

Original languageEnglish
Pages (from-to)425-430
Number of pages6
JournalAdvanced Materials
Issue number4
Publication statusPublished - Jan 26 2009

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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