Esterase-activated release of naproxen from supramolecular nanofibres

Martin Conda-Sheridan, Sungsoo S. Lee, Adam T. Preslar, Samuel I Stupp

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Nanofibre forming peptide amphiphiles were conjugated to naproxen through an esterase-sensitive linker. The amount of naproxen released, in the presence of enzymes, was influenced by the linker conjugating the drug to the supramolecular assembly. In vitro studies showed the anti-inflammatory activity of the released drug was maintained. This journal is

Original languageEnglish
Pages (from-to)13757-13760
Number of pages4
JournalChemical Communications
Volume50
Issue number89
DOIs
Publication statusPublished - Nov 18 2014

Fingerprint

Nanofibers
Amphiphiles
Naproxen
Esterases
Peptides
Enzymes
Carboxylesterase
Pharmaceutical Preparations
Anti-Inflammatory Agents
In Vitro Techniques

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys
  • Medicine(all)

Cite this

Esterase-activated release of naproxen from supramolecular nanofibres. / Conda-Sheridan, Martin; Lee, Sungsoo S.; Preslar, Adam T.; Stupp, Samuel I.

In: Chemical Communications, Vol. 50, No. 89, 18.11.2014, p. 13757-13760.

Research output: Contribution to journalArticle

Conda-Sheridan, Martin ; Lee, Sungsoo S. ; Preslar, Adam T. ; Stupp, Samuel I. / Esterase-activated release of naproxen from supramolecular nanofibres. In: Chemical Communications. 2014 ; Vol. 50, No. 89. pp. 13757-13760.
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