Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: A time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO) 3(F 2dppz)(py)] + bound to either [poly(dA-dT)] 2 or [poly(dG-dC)] 2

Qian Cao, Caitriona M. Creely, E. Stephen Davies, Joanne Dyer, Timothy L. Easun, David Grills, David A. McGovern, Jonathan McMaster, Jonathan Pitchford, Jayden A. Smith, Xue Zhong Sun, John M. Kelly, Michael W. George

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The transient species formed following excitation of fac-[Re(CO) 3(F 2dppz)(py)] + (F 2dppz = 11,12-difluorodipyrido[3,2-a:2′,3′-c]phenazine) bound to double-stranded polynucleotides [poly(dA-dT)] 2 or [poly(dG-dC)] 2 have been studied by transient visible and infra-red spectroscopy in both the picosecond and nanosecond time domains. The latter technique has been used to monitor both the metal complex and the DNA by monitoring the regions 1900-2100 and 1500-1750 cm -1 respectively. These data provide direct evidence for electron transfer from guanine to the excited state of the metal complex, which proceeds both on a sub-picosecond time scale and with a lifetime of 35 ps, possibly due to the involvement of two excited states. No electron transfer is found for the [poly(dA-dT)] 2 complex, although characteristic changes are seen in the DNA-region TRIR consistent with changes in the binding of the bases in the intercalation site upon excitation of the dppz-complex.

Original languageEnglish
Pages (from-to)1355-1364
Number of pages10
JournalPhotochemical and Photobiological Sciences
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 2011

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Poly dA-dT
Rhenium
Coordination Complexes
rhenium
Carbon Monoxide
Excited states
electron transfer
deoxyribonucleic acid
Polynucleotides
Electrons
DNA
Guanine
Intercalation
excitation
Infrared spectroscopy
polynucleotides
Monitoring
guanines
intercalation
metals

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

Cite this

Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA : A time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO) 3(F 2dppz)(py)] + bound to either [poly(dA-dT)] 2 or [poly(dG-dC)] 2. / Cao, Qian; Creely, Caitriona M.; Davies, E. Stephen; Dyer, Joanne; Easun, Timothy L.; Grills, David; McGovern, David A.; McMaster, Jonathan; Pitchford, Jonathan; Smith, Jayden A.; Sun, Xue Zhong; Kelly, John M.; George, Michael W.

In: Photochemical and Photobiological Sciences, Vol. 10, No. 8, 08.2011, p. 1355-1364.

Research output: Contribution to journalArticle

Cao, Qian ; Creely, Caitriona M. ; Davies, E. Stephen ; Dyer, Joanne ; Easun, Timothy L. ; Grills, David ; McGovern, David A. ; McMaster, Jonathan ; Pitchford, Jonathan ; Smith, Jayden A. ; Sun, Xue Zhong ; Kelly, John M. ; George, Michael W. / Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA : A time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO) 3(F 2dppz)(py)] + bound to either [poly(dA-dT)] 2 or [poly(dG-dC)] 2. In: Photochemical and Photobiological Sciences. 2011 ; Vol. 10, No. 8. pp. 1355-1364.
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