Folding and unfolding of an elastinlike oligopeptide

"inverse temperature transition," reentrance, and hydrogen-bond dynamics

Eduard Schreiner, Chiara Nicolini, Björn Ludolph, Revanur Ravindra, Nikolaj Otte, Axel Kohlmeyer, Roger Rousseau, Roland Winter, Dominik Marx

Research output: Contribution to journalArticle

Abstract

The temperature-dependent behavior of a solvated oligopeptide, GVG(VPGVG), is investigated. Spectroscopic measurements, thermodynamic measurements, and molecular dynamics simulations find that this elastinlike octapeptide behaves as a two-state system that undergoes an "inverse temperature" folding transition and reentrant unfolding close to the boiling point of water. A molecular picture of these processes is presented, emphasizing changes in the dynamics of hydrogen bonding at the protein/water interface and peptide backbone librational entropy.

Original languageEnglish
Pages (from-to)148101
Number of pages1
JournalPhysical Review Letters
Volume92
Issue number14
Publication statusPublished - Apr 9 2004

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Oligopeptides
Transition Temperature
valyl-prolyl-glycyl-valyl-glycine
folding
Hydrogen
transition temperature
hydrogen bonds
Water
Entropy
Molecular Dynamics Simulation
Hydrogen Bonding
Thermodynamics
boiling
water
peptides
entropy
molecular dynamics
proteins
thermodynamics
Peptides

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Schreiner, E., Nicolini, C., Ludolph, B., Ravindra, R., Otte, N., Kohlmeyer, A., ... Marx, D. (2004). Folding and unfolding of an elastinlike oligopeptide: "inverse temperature transition," reentrance, and hydrogen-bond dynamics. Physical Review Letters, 92(14), 148101.

Folding and unfolding of an elastinlike oligopeptide : "inverse temperature transition," reentrance, and hydrogen-bond dynamics. / Schreiner, Eduard; Nicolini, Chiara; Ludolph, Björn; Ravindra, Revanur; Otte, Nikolaj; Kohlmeyer, Axel; Rousseau, Roger; Winter, Roland; Marx, Dominik.

In: Physical Review Letters, Vol. 92, No. 14, 09.04.2004, p. 148101.

Research output: Contribution to journalArticle

Schreiner, E, Nicolini, C, Ludolph, B, Ravindra, R, Otte, N, Kohlmeyer, A, Rousseau, R, Winter, R & Marx, D 2004, 'Folding and unfolding of an elastinlike oligopeptide: "inverse temperature transition," reentrance, and hydrogen-bond dynamics', Physical Review Letters, vol. 92, no. 14, pp. 148101.
Schreiner E, Nicolini C, Ludolph B, Ravindra R, Otte N, Kohlmeyer A et al. Folding and unfolding of an elastinlike oligopeptide: "inverse temperature transition," reentrance, and hydrogen-bond dynamics. Physical Review Letters. 2004 Apr 9;92(14):148101.
Schreiner, Eduard ; Nicolini, Chiara ; Ludolph, Björn ; Ravindra, Revanur ; Otte, Nikolaj ; Kohlmeyer, Axel ; Rousseau, Roger ; Winter, Roland ; Marx, Dominik. / Folding and unfolding of an elastinlike oligopeptide : "inverse temperature transition," reentrance, and hydrogen-bond dynamics. In: Physical Review Letters. 2004 ; Vol. 92, No. 14. pp. 148101.
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