Folding and unfolding of an elastinlike oligopeptide: "inverse temperature transition," reentrance, and hydrogen-bond dynamics

Eduard Schreiner, Chiara Nicolini, Björn Ludolph, Revanur Ravindra, Nikolaj Otte, Axel Kohlmeyer, Roger Rousseau, Roland Winter, Dominik Marx

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Abstract

The temperature-dependent behavior of an oligopeptide GVG(VPGVG) was discussed. Spectroscopic measurements, thermodynamic measurements, and molecular dynamics simulations reveal that this octapeptide behaves as a two-state system. The system was found to undergo an 'inverse temperature' folding transition and reentrant unfolding. A molecular picture of these processes was also presented.

Original languageEnglish
Article number154101
Pages (from-to)148101-1-148101-4
JournalPhysical review letters
Volume92
Issue number14
DOIs
Publication statusPublished - Apr 9 2004

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ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Schreiner, E., Nicolini, C., Ludolph, B., Ravindra, R., Otte, N., Kohlmeyer, A., Rousseau, R., Winter, R., & Marx, D. (2004). Folding and unfolding of an elastinlike oligopeptide: "inverse temperature transition," reentrance, and hydrogen-bond dynamics. Physical review letters, 92(14), 148101-1-148101-4. [154101]. https://doi.org/10.1103/PhysRevLett.92.148101