Folding and unfolding of an elastinlike oligopeptide: "inverse temperature transition," reentrance, and hydrogen-bond dynamics

Eduard Schreiner, Chiara Nicolini, Björn Ludolph, Revanur Ravindra, Nikolaj Otte, Axel Kohlmeyer, Roger Rousseau, Roland Winter, Dominik Marx

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The temperature-dependent behavior of an oligopeptide GVG(VPGVG) was discussed. Spectroscopic measurements, thermodynamic measurements, and molecular dynamics simulations reveal that this octapeptide behaves as a two-state system. The system was found to undergo an 'inverse temperature' folding transition and reentrant unfolding. A molecular picture of these processes was also presented.

Original languageEnglish
Pages (from-to)148101
Number of pages1
JournalPhysical Review Letters
Volume92
Issue number14
DOIs
Publication statusPublished - Apr 9 2004

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folding
transition temperature
hydrogen bonds
molecular dynamics
thermodynamics
temperature
simulation

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Folding and unfolding of an elastinlike oligopeptide : "inverse temperature transition," reentrance, and hydrogen-bond dynamics. / Schreiner, Eduard; Nicolini, Chiara; Ludolph, Björn; Ravindra, Revanur; Otte, Nikolaj; Kohlmeyer, Axel; Rousseau, Roger; Winter, Roland; Marx, Dominik.

In: Physical Review Letters, Vol. 92, No. 14, 09.04.2004, p. 148101.

Research output: Contribution to journalArticle

Schreiner, Eduard ; Nicolini, Chiara ; Ludolph, Björn ; Ravindra, Revanur ; Otte, Nikolaj ; Kohlmeyer, Axel ; Rousseau, Roger ; Winter, Roland ; Marx, Dominik. / Folding and unfolding of an elastinlike oligopeptide : "inverse temperature transition," reentrance, and hydrogen-bond dynamics. In: Physical Review Letters. 2004 ; Vol. 92, No. 14. pp. 148101.
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