General Synthesis of Amino Acid Salts from Amino Alcohols and Basic Water Liberating H2

Peng Hu, Yehoshoa Ben-David, David Milstein

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

An atom-economical and environmentally friendly method to transform amino alcohols to amino acid salts using just basic water, without the need of pre-protection or added oxidant, catalyzed by a ruthenium pincer complex, is developed. Water is the solvent, the source of the oxygen atom of the carboxylic acid group, and the actual oxidant, with liberation of dihydrogen. Many important and useful natural and unnatural amino acid salts can be produced in excellent yields by applying this new method.

Original languageEnglish
Pages (from-to)6143-6146
Number of pages4
JournalJournal of the American Chemical Society
Volume138
Issue number19
DOIs
Publication statusPublished - May 18 2016

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

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