Generalized approach to SERS-active nanomaterials via controlled nanoparticle linking, polymer encapsulation, and small-molecule infusion

Martin Moskovits, Gary B. Braun, Seung Joon Lee, Ted Laurence, Nick Fera, Laura Fabris, Guillermo C. Bazan, Norbert O. Reich

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Over the past decade the emphasis on single-molecule sensitivity of surface-enhanced Raman spectroscopy (SERS) has brought to prominence the special role played by so-called SERS hot spots, oftentimes nanometer-scale junctions between nanoparticles (NPs). In this report, molecular linkers are used to mediate the assembly of NPs to dimers and small clusters. When the SERS enhancement is optimized, the aggregation process is quenched by polymer and protein stabilizers that subsequently act as encapsulants resulting in SERS substates with unprecedented enhancement uniformity, reproducibility, and stability. The polymer-stabilized NP junctions were then imprinted with a variety of small molecules that permeated the polymer coat and displaced the linker from the hot spot. The average SERS enhancement of these SERS "nanocapsules" was found to be at least 300× greater than for single NPs, while the Raman/Rayleigh scattering ratio was 104 higher for linked NPs versus nonoptimized aggregates. Single-particle statistics showed that almost every nanocapsule produced intense SERS, suggesting that they are NP dimers and small clusters with the probe molecule resident in a hot spot. Nanocapsules were functionalized and shown to compete successfully with fluorescence imaging in multiplexed identification of cancer cell epitopes at the single-cell and single-nanotag level.

Original languageEnglish
Pages (from-to)13622-13629
Number of pages8
JournalJournal of Physical Chemistry C
Volume113
Issue number31
DOIs
Publication statusPublished - Aug 6 2009

Fingerprint

Encapsulation
Nanostructured materials
Raman spectroscopy
Polymers
Nanoparticles
nanoparticles
Molecules
Nanocapsules
polymers
molecules
Dimers
augmentation
dimers
Epitopes
Rayleigh scattering
Raman scattering
Agglomeration
assembly
cancer
Fluorescence

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Energy(all)

Cite this

Generalized approach to SERS-active nanomaterials via controlled nanoparticle linking, polymer encapsulation, and small-molecule infusion. / Moskovits, Martin; Braun, Gary B.; Lee, Seung Joon; Laurence, Ted; Fera, Nick; Fabris, Laura; Bazan, Guillermo C.; Reich, Norbert O.

In: Journal of Physical Chemistry C, Vol. 113, No. 31, 06.08.2009, p. 13622-13629.

Research output: Contribution to journalArticle

Moskovits, Martin ; Braun, Gary B. ; Lee, Seung Joon ; Laurence, Ted ; Fera, Nick ; Fabris, Laura ; Bazan, Guillermo C. ; Reich, Norbert O. / Generalized approach to SERS-active nanomaterials via controlled nanoparticle linking, polymer encapsulation, and small-molecule infusion. In: Journal of Physical Chemistry C. 2009 ; Vol. 113, No. 31. pp. 13622-13629.
@article{dcc27196db47432c97cea56ccd6df29b,
title = "Generalized approach to SERS-active nanomaterials via controlled nanoparticle linking, polymer encapsulation, and small-molecule infusion",
abstract = "Over the past decade the emphasis on single-molecule sensitivity of surface-enhanced Raman spectroscopy (SERS) has brought to prominence the special role played by so-called SERS hot spots, oftentimes nanometer-scale junctions between nanoparticles (NPs). In this report, molecular linkers are used to mediate the assembly of NPs to dimers and small clusters. When the SERS enhancement is optimized, the aggregation process is quenched by polymer and protein stabilizers that subsequently act as encapsulants resulting in SERS substates with unprecedented enhancement uniformity, reproducibility, and stability. The polymer-stabilized NP junctions were then imprinted with a variety of small molecules that permeated the polymer coat and displaced the linker from the hot spot. The average SERS enhancement of these SERS {"}nanocapsules{"} was found to be at least 300× greater than for single NPs, while the Raman/Rayleigh scattering ratio was 104 higher for linked NPs versus nonoptimized aggregates. Single-particle statistics showed that almost every nanocapsule produced intense SERS, suggesting that they are NP dimers and small clusters with the probe molecule resident in a hot spot. Nanocapsules were functionalized and shown to compete successfully with fluorescence imaging in multiplexed identification of cancer cell epitopes at the single-cell and single-nanotag level.",
author = "Martin Moskovits and Braun, {Gary B.} and Lee, {Seung Joon} and Ted Laurence and Nick Fera and Laura Fabris and Bazan, {Guillermo C.} and Reich, {Norbert O.}",
year = "2009",
month = "8",
day = "6",
doi = "10.1021/jp903399p",
language = "English",
volume = "113",
pages = "13622--13629",
journal = "Journal of Physical Chemistry C",
issn = "1932-7447",
publisher = "American Chemical Society",
number = "31",

}

TY - JOUR

T1 - Generalized approach to SERS-active nanomaterials via controlled nanoparticle linking, polymer encapsulation, and small-molecule infusion

AU - Moskovits, Martin

AU - Braun, Gary B.

AU - Lee, Seung Joon

AU - Laurence, Ted

AU - Fera, Nick

AU - Fabris, Laura

AU - Bazan, Guillermo C.

AU - Reich, Norbert O.

PY - 2009/8/6

Y1 - 2009/8/6

N2 - Over the past decade the emphasis on single-molecule sensitivity of surface-enhanced Raman spectroscopy (SERS) has brought to prominence the special role played by so-called SERS hot spots, oftentimes nanometer-scale junctions between nanoparticles (NPs). In this report, molecular linkers are used to mediate the assembly of NPs to dimers and small clusters. When the SERS enhancement is optimized, the aggregation process is quenched by polymer and protein stabilizers that subsequently act as encapsulants resulting in SERS substates with unprecedented enhancement uniformity, reproducibility, and stability. The polymer-stabilized NP junctions were then imprinted with a variety of small molecules that permeated the polymer coat and displaced the linker from the hot spot. The average SERS enhancement of these SERS "nanocapsules" was found to be at least 300× greater than for single NPs, while the Raman/Rayleigh scattering ratio was 104 higher for linked NPs versus nonoptimized aggregates. Single-particle statistics showed that almost every nanocapsule produced intense SERS, suggesting that they are NP dimers and small clusters with the probe molecule resident in a hot spot. Nanocapsules were functionalized and shown to compete successfully with fluorescence imaging in multiplexed identification of cancer cell epitopes at the single-cell and single-nanotag level.

AB - Over the past decade the emphasis on single-molecule sensitivity of surface-enhanced Raman spectroscopy (SERS) has brought to prominence the special role played by so-called SERS hot spots, oftentimes nanometer-scale junctions between nanoparticles (NPs). In this report, molecular linkers are used to mediate the assembly of NPs to dimers and small clusters. When the SERS enhancement is optimized, the aggregation process is quenched by polymer and protein stabilizers that subsequently act as encapsulants resulting in SERS substates with unprecedented enhancement uniformity, reproducibility, and stability. The polymer-stabilized NP junctions were then imprinted with a variety of small molecules that permeated the polymer coat and displaced the linker from the hot spot. The average SERS enhancement of these SERS "nanocapsules" was found to be at least 300× greater than for single NPs, while the Raman/Rayleigh scattering ratio was 104 higher for linked NPs versus nonoptimized aggregates. Single-particle statistics showed that almost every nanocapsule produced intense SERS, suggesting that they are NP dimers and small clusters with the probe molecule resident in a hot spot. Nanocapsules were functionalized and shown to compete successfully with fluorescence imaging in multiplexed identification of cancer cell epitopes at the single-cell and single-nanotag level.

UR - http://www.scopus.com/inward/record.url?scp=68749083557&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68749083557&partnerID=8YFLogxK

U2 - 10.1021/jp903399p

DO - 10.1021/jp903399p

M3 - Article

VL - 113

SP - 13622

EP - 13629

JO - Journal of Physical Chemistry C

JF - Journal of Physical Chemistry C

SN - 1932-7447

IS - 31

ER -