Glutathione-triggered release of model drug molecules from mesoporous silica nanoparticles via a non-redox process

Xiaoxi Huang, Tao Zhang, Anandarup Goswami, Feixiang Luo, Teddy Asefa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Model drug-loaded mesoporous silica nanoparticles (MSNs) that are responsive to the pH rather than the redox changes normally related to glutathione (GSH) are prepared using surfactant-free MSNs as precursor. The nanoparticles are successfully shown to serve as GSH-triggered release vehicles for the guest molecules. Unlike the generally known GSH-based redox-triggered drug release action, a non-redox, ionic process associated with GSH and GSH-induced pH change enables the MSNs to release their guest molecules.

Original languageEnglish
Pages (from-to)28836-28839
Number of pages4
JournalRSC Advances
Volume5
Issue number36
DOIs
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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