Abstract
Model drug-loaded mesoporous silica nanoparticles (MSNs) that are responsive to the pH rather than the redox changes normally related to glutathione (GSH) are prepared using surfactant-free MSNs as precursor. The nanoparticles are successfully shown to serve as GSH-triggered release vehicles for the guest molecules. Unlike the generally known GSH-based redox-triggered drug release action, a non-redox, ionic process associated with GSH and GSH-induced pH change enables the MSNs to release their guest molecules.
| Original language | English |
|---|---|
| Pages (from-to) | 28836-28839 |
| Number of pages | 4 |
| Journal | RSC Advances |
| Volume | 5 |
| Issue number | 36 |
| DOIs | |
| Publication status | Published - 2015 |
ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)
Fingerprint Dive into the research topics of 'Glutathione-triggered release of model drug molecules from mesoporous silica nanoparticles via a non-redox process'. Together they form a unique fingerprint.
Cite this
Huang, X., Zhang, T., Goswami, A., Luo, F., & Asefa, T. (2015). Glutathione-triggered release of model drug molecules from mesoporous silica nanoparticles via a non-redox process. RSC Advances, 5(36), 28836-28839. https://doi.org/10.1039/c4ra08570a