Glutathione-triggered release of model drug molecules from mesoporous silica nanoparticles via a non-redox process

Xiaoxi Huang, Tao Zhang, Anandarup Goswami, Feixiang Luo, Teddy Asefa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Model drug-loaded mesoporous silica nanoparticles (MSNs) that are responsive to the pH rather than the redox changes normally related to glutathione (GSH) are prepared using surfactant-free MSNs as precursor. The nanoparticles are successfully shown to serve as GSH-triggered release vehicles for the guest molecules. Unlike the generally known GSH-based redox-triggered drug release action, a non-redox, ionic process associated with GSH and GSH-induced pH change enables the MSNs to release their guest molecules.

Original languageEnglish
Pages (from-to)28836-28839
Number of pages4
JournalRSC Advances
Volume5
Issue number36
DOIs
Publication statusPublished - 2015

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Silicon Dioxide
Glutathione
Silica
Nanoparticles
Molecules
Pharmaceutical Preparations
Surface-Active Agents
Surface active agents
Oxidation-Reduction

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Glutathione-triggered release of model drug molecules from mesoporous silica nanoparticles via a non-redox process. / Huang, Xiaoxi; Zhang, Tao; Goswami, Anandarup; Luo, Feixiang; Asefa, Teddy.

In: RSC Advances, Vol. 5, No. 36, 2015, p. 28836-28839.

Research output: Contribution to journalArticle

Huang, Xiaoxi ; Zhang, Tao ; Goswami, Anandarup ; Luo, Feixiang ; Asefa, Teddy. / Glutathione-triggered release of model drug molecules from mesoporous silica nanoparticles via a non-redox process. In: RSC Advances. 2015 ; Vol. 5, No. 36. pp. 28836-28839.
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