Glutathione-triggered release of model drug molecules from mesoporous silica nanoparticles via a non-redox process

Xiaoxi Huang; Tao Zhang; Anandarup Goswami; Feixiang Luo; Tewodros Asefa

doi:10.1039/c4ra08570a

Glutathione-triggered release of model drug molecules from mesoporous silica nanoparticles via a non-redox process

Xiaoxi Huang, Tao Zhang, Anandarup Goswami, Feixiang Luo, Tewodros Asefa

Rutgers University

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Model drug-loaded mesoporous silica nanoparticles (MSNs) that are responsive to the pH rather than the redox changes normally related to glutathione (GSH) are prepared using surfactant-free MSNs as precursor. The nanoparticles are successfully shown to serve as GSH-triggered release vehicles for the guest molecules. Unlike the generally known GSH-based redox-triggered drug release action, a non-redox, ionic process associated with GSH and GSH-induced pH change enables the MSNs to release their guest molecules.

Original language	English
Pages (from-to)	28836-28839
Number of pages	4
Journal	RSC Advances
Volume	5
Issue number	36
DOIs	https://doi.org/10.1039/c4ra08570a
Publication status	Published - 2015

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)

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AU - Asefa, Tewodros

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