Abstract
Model drug-loaded mesoporous silica nanoparticles (MSNs) that are responsive to the pH rather than the redox changes normally related to glutathione (GSH) are prepared using surfactant-free MSNs as precursor. The nanoparticles are successfully shown to serve as GSH-triggered release vehicles for the guest molecules. Unlike the generally known GSH-based redox-triggered drug release action, a non-redox, ionic process associated with GSH and GSH-induced pH change enables the MSNs to release their guest molecules.
| Original language | English |
|---|---|
| Pages (from-to) | 28836-28839 |
| Number of pages | 4 |
| Journal | RSC Advances |
| Volume | 5 |
| Issue number | 36 |
| DOIs | |
| Publication status | Published - 2015 |
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ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)
Cite this
Glutathione-triggered release of model drug molecules from mesoporous silica nanoparticles via a non-redox process. / Huang, Xiaoxi; Zhang, Tao; Goswami, Anandarup; Luo, Feixiang; Asefa, Teddy.
In: RSC Advances, Vol. 5, No. 36, 2015, p. 28836-28839.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Glutathione-triggered release of model drug molecules from mesoporous silica nanoparticles via a non-redox process
AU - Huang, Xiaoxi
AU - Zhang, Tao
AU - Goswami, Anandarup
AU - Luo, Feixiang
AU - Asefa, Teddy
PY - 2015
Y1 - 2015
N2 - Model drug-loaded mesoporous silica nanoparticles (MSNs) that are responsive to the pH rather than the redox changes normally related to glutathione (GSH) are prepared using surfactant-free MSNs as precursor. The nanoparticles are successfully shown to serve as GSH-triggered release vehicles for the guest molecules. Unlike the generally known GSH-based redox-triggered drug release action, a non-redox, ionic process associated with GSH and GSH-induced pH change enables the MSNs to release their guest molecules.
AB - Model drug-loaded mesoporous silica nanoparticles (MSNs) that are responsive to the pH rather than the redox changes normally related to glutathione (GSH) are prepared using surfactant-free MSNs as precursor. The nanoparticles are successfully shown to serve as GSH-triggered release vehicles for the guest molecules. Unlike the generally known GSH-based redox-triggered drug release action, a non-redox, ionic process associated with GSH and GSH-induced pH change enables the MSNs to release their guest molecules.
UR - http://www.scopus.com/inward/record.url?scp=84961291695&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961291695&partnerID=8YFLogxK
U2 - 10.1039/c4ra08570a
DO - 10.1039/c4ra08570a
M3 - Article
VL - 5
SP - 28836
EP - 28839
JO - RSC Advances
JF - RSC Advances
SN - 2046-2069
IS - 36
ER -