Abstract
Model drug-loaded mesoporous silica nanoparticles (MSNs) that are responsive to the pH rather than the redox changes normally related to glutathione (GSH) are prepared using surfactant-free MSNs as precursor. The nanoparticles are successfully shown to serve as GSH-triggered release vehicles for the guest molecules. Unlike the generally known GSH-based redox-triggered drug release action, a non-redox, ionic process associated with GSH and GSH-induced pH change enables the MSNs to release their guest molecules.
Original language | English |
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Pages (from-to) | 28836-28839 |
Number of pages | 4 |
Journal | RSC Advances |
Volume | 5 |
Issue number | 36 |
DOIs | |
Publication status | Published - 2015 |
ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)