Abstract
The preparation and properties of a series of gold nanoclusters protected by thiolated peptides based on the α-aminoisobutyric acid (Aib) unit are described. The peptides were devised to form 0-3 C=O⋯H-N intramolecular hydrogen bonds, as required by their 310-helical structure. The monolayer-protected clusters (MPCs) were prepared, using a modified version of the two-phase Brust-Schiffrin preparation, and fully characterized with 1H NMR spectrometry, IR and UV-vis absorption spectroscopies, transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and X-ray photoelectron spectroscopy (XPS). The MPCs were obtained with core diameters in the range of 1.1-2.3 nm, depending on the reaction conditions. Structured peptides formed smaller clusters. The smallest MPC obtained is in agreement with the average formula Au38PeP18. The results showed that the chemical integrity of the peptide is maintained upon monolayer formation and that the average number of peptide ligands per gold cluster is typically 75-85% the value calculated for alkanethiolate MPCs of similar sizes. The IR and NMR spectra indicated that in the monolayer the peptides are involved in both intra- and interligand C=O-H-N hydrogen bonds.
| Original language | English |
|---|---|
| Pages (from-to) | 326-336 |
| Number of pages | 11 |
| Journal | Journal of the American Chemical Society |
| Volume | 128 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 11 2006 |
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ASJC Scopus subject areas
- Chemistry(all)
Cite this
Gold nanoclusters protected by conformationally constrained peptides. / Fabris, Laura; Antonello, Sabrina; Armelao, Lidia; Donkers, Robert L.; Polo, Federico; Toniolo, Claudio; Maran, Flavio.
In: Journal of the American Chemical Society, Vol. 128, No. 1, 11.01.2006, p. 326-336.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gold nanoclusters protected by conformationally constrained peptides
AU - Fabris, Laura
AU - Antonello, Sabrina
AU - Armelao, Lidia
AU - Donkers, Robert L.
AU - Polo, Federico
AU - Toniolo, Claudio
AU - Maran, Flavio
PY - 2006/1/11
Y1 - 2006/1/11
N2 - The preparation and properties of a series of gold nanoclusters protected by thiolated peptides based on the α-aminoisobutyric acid (Aib) unit are described. The peptides were devised to form 0-3 C=O⋯H-N intramolecular hydrogen bonds, as required by their 310-helical structure. The monolayer-protected clusters (MPCs) were prepared, using a modified version of the two-phase Brust-Schiffrin preparation, and fully characterized with 1H NMR spectrometry, IR and UV-vis absorption spectroscopies, transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and X-ray photoelectron spectroscopy (XPS). The MPCs were obtained with core diameters in the range of 1.1-2.3 nm, depending on the reaction conditions. Structured peptides formed smaller clusters. The smallest MPC obtained is in agreement with the average formula Au38PeP18. The results showed that the chemical integrity of the peptide is maintained upon monolayer formation and that the average number of peptide ligands per gold cluster is typically 75-85% the value calculated for alkanethiolate MPCs of similar sizes. The IR and NMR spectra indicated that in the monolayer the peptides are involved in both intra- and interligand C=O-H-N hydrogen bonds.
AB - The preparation and properties of a series of gold nanoclusters protected by thiolated peptides based on the α-aminoisobutyric acid (Aib) unit are described. The peptides were devised to form 0-3 C=O⋯H-N intramolecular hydrogen bonds, as required by their 310-helical structure. The monolayer-protected clusters (MPCs) were prepared, using a modified version of the two-phase Brust-Schiffrin preparation, and fully characterized with 1H NMR spectrometry, IR and UV-vis absorption spectroscopies, transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and X-ray photoelectron spectroscopy (XPS). The MPCs were obtained with core diameters in the range of 1.1-2.3 nm, depending on the reaction conditions. Structured peptides formed smaller clusters. The smallest MPC obtained is in agreement with the average formula Au38PeP18. The results showed that the chemical integrity of the peptide is maintained upon monolayer formation and that the average number of peptide ligands per gold cluster is typically 75-85% the value calculated for alkanethiolate MPCs of similar sizes. The IR and NMR spectra indicated that in the monolayer the peptides are involved in both intra- and interligand C=O-H-N hydrogen bonds.
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U2 - 10.1021/ja0560581
DO - 10.1021/ja0560581
M3 - Article
VL - 128
SP - 326
EP - 336
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 1
ER -