Widespread scientific consensus has identified the most challenging barrier to renewable hydrogen fuel generation from water as the oxygen-evolving half reaction. In this talk I will summarize scientific and engineering progress towards realizing practical advances in H2 production from water using a bioinspired abiotic catalyst. Strongly oxidizing inorganic materials, inspired by the photosynthetic oxygen-evolving enzyme, have been synthesized possessing the cubical [Mn4O4]7+ core type. These have been integrated into a photoelectrochemical cell and shown to catalyze the electrooxidation of water. Current generation materials are able to catalyze the sustained photo-assisted oxidation of water for several thousand turnovers. Catalyst integration within a photovoltaic cell (dye-sensitized TiO2) enables photoproduction of hydrogen from water using visible light. Improvements to these inexpensive "green" catalysts are in development as replacement for expensive, non-scalable, noble metals for renewable hydrogen production from water, and in fuel cells for overcoming the cathodic overpotential for reduction of oxygen.